Compound
glyoxylic acid
A 2-oxo monocarboxylic acid that is acetic acid bearing an oxo group at the α carbon atom.
Definition from ChEBI (CHEBI:16891), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- AGXTProteinUNIPROT:P21549substrate ofInferred only24 paths12 endpoints
- LDHBProteinUNIPROT:P07195substrate ofInferred only23 paths23 endpoints
- GRHPRProteinUNIPROT:Q9UBQ7substrate ofInferred only14 paths7 endpoints
- LDHCProteinUNIPROT:P07864substrate ofInferred only9 paths9 endpoints
- AGXT2ProteinUNIPROT:Q9BYV1substrate ofInferred only8 paths8 endpoints
- HAO1ProteinUNIPROT:Q9UJM8substrate ofInferred only6 paths6 endpoints
- LDHDProteinUNIPROT:Q86WU2substrate ofInferred only5 paths5 endpoints
- LDHAL6BProteinUNIPROT:Q9BYZ2substrate ofInferred only5 paths5 endpoints
- LDHAL6AProteinUNIPROT:Q6ZMR3substrate ofInferred only3 paths3 endpoints
What the reference databases state
Statements
20 statements
20 statements · 1 reference database · Subject: glyoxylic acid · Sources: Human-GEM
- glycine is converted to glyoxylic acidCompoundHuman-GEM MAR04789Inferred only
- glycolate is converted to glyoxylic acidCompoundHuman-GEM MAR07706Inferred only
- glycolate is converted to glyoxylic acidCompoundHuman-GEM MAR07703Inferred only
- glyoxylic acid is converted to glycolateCompoundHuman-GEM MAR08779Inferred only
- glyoxylic acid is converted to glycolateCompoundHuman-GEM MAR07702Inferred only
- glycolate is converted to glyoxylic acidCompoundHuman-GEM MAR07702Inferred only
- glyoxylic acid is converted to oxalic acidCompoundHuman-GEM MAR08780Inferred only
- glyoxylic acid is converted to oxalic acidCompoundHuman-GEM MAR07704Inferred only
- glyoxylic acid is a substrate of AGXTProteinHuman-GEM MAR04788Inferred only
- glyoxylic acid is a substrate of AGXTProteinHuman-GEM MAR04791Inferred only
- glyoxylic acid is a substrate of AGXT2ProteinHuman-GEM MAR04788Inferred only
- glyoxylic acid is a substrate of CLYBLProteinHuman-GEM MAR20111Inferred only
Show the remaining 8
- glyoxylic acid is a substrate of GRHPRProteinHuman-GEM MAR08779Inferred only
- glyoxylic acid is a substrate of GRHPRProteinHuman-GEM MAR07702Inferred only
- glyoxylic acid is a substrate of HAO1ProteinHuman-GEM MAR07704Inferred only
- glyoxylic acid is a substrate of LDHAL6AProteinHuman-GEM MAR08780Inferred only
- glyoxylic acid is a substrate of LDHAL6BProteinHuman-GEM MAR08780Inferred only
- glyoxylic acid is a substrate of LDHBProteinHuman-GEM MAR08780Inferred only
- glyoxylic acid is a substrate of LDHCProteinHuman-GEM MAR08780Inferred only
- glyoxylic acid is a substrate of LDHDProteinHuman-GEM MAR08780Inferred only
Reactions
15 reactions
4-hydroxy-2-oxoglutaric acidglyoxylic acid+pyruvate
Catalysed by HOGA1
Reaction pageLeft to rightBalancedEC 4.1.3.16mitochondrial matrix
Human-GEM MAR04787CC BY 4.0Reference data
L-alanine+glyoxylic acidglycine+pyruvate
Reaction pageLeft to rightBalancedEC 2.6.1.44mitochondrial matrix
Human-GEM MAR04788CC BY 4.0Reference data
FAD+glycine+waterFADH2+glyoxylic acid+proton+ammonium
Catalysed by DAO
Reaction pageLeft to rightBalancedEC 1.4.3.3peroxisome
Human-GEM MAR04789CC BY 4.0Reference data
L-alanine+glyoxylic acidglycine+pyruvate
Catalysed by AGXT
Reaction pageLeft to rightBalancedEC 2.6.1.44peroxisome
Human-GEM MAR04791CC BY 4.0Reference data
glyoxylic acid+proton+NADPH(4-)glycolate+NADP(3-)
Catalysed by GRHPR
Reaction pageReversibleBalancedEC 1.1.1.79, 1.1.1.81cytosol
Human-GEM MAR07702CC BY 4.0Reference data
glycolate+dioxygenglyoxylic acid+hydrogen peroxide
Catalysed by HAO1
Reaction pageLeft to rightBalancedEC 1.1.3.15cytosol
Human-GEM MAR07703CC BY 4.0Reference data
FAD+glyoxylic acid+waterFADH2+proton+oxalic acid
Catalysed by HAO1
Reaction pageLeft to rightBalancedEC 1.1.3.15peroxisome
Human-GEM MAR07704CC BY 4.0Reference data
FAD+glycolateFADH2+glyoxylic acid
Catalysed by HAO1
Reaction pageLeft to rightBalancedEC 1.1.3.15peroxisome
Human-GEM MAR07706CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR07707CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR07708CC BY 4.0Reference data
glyoxylic acid+proton+NADPH(4-)glycolate+NADP(3-)
Catalysed by GRHPR
Reaction pageLeft to rightBalancedEC 1.1.1.79mitochondrial matrix
Human-GEM MAR08779CC BY 4.0Reference data
glyoxylic acid+water+NAD(+)2proton+NADH(2-)+oxalic acid
Catalysed by LDHB or LDHC or LDHAL6A or LDHD or LDHAL6B
Reaction pageLeft to rightBalancedEC 1.1.1.27cytosol
Human-GEM MAR08780CC BY 4.0Reference data
Other names
8 names
Resolves to: glyoxylic acid
- Also called
- alpha-ketoacetic acidformylformic acidGlyoxalateGlyoxylateoxalaldehydic acidoxoethanoic acidα-ketoacetic acid
- Systematic name
- oxoacetic acid