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Proteins/UNIPROT:Q02127
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway..
Function from UniProtKB (Q02127), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
27 statements
27 statements · 7 reference databases · Subject: DHODH · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
(S)-dihydroorotate+CHEBI:17621orotic acid+FMNH2
Catalysed by DHODH
Reaction pageReversibleBalancedEC 1.3.5.2, 1.3.1.14cytosol
Human-GEM MAR04575CC BY 4.0Reference data
3 names
Resolves to: DHODH
Reaction pageReversibleBalancedEC 1.5.5.1mitochondrial matrix
Human-GEM MAR06911CC BY 4.0Reference data
ubiquinones+FMNH2CHEBI:17621+ubiquinol
Catalysed by DHODH
Reaction pageReversibleBalancedEC 1.3.5.2mitochondrial matrix, cytosol
Human-GEM MAR20167CC BY 4.0Reference data
(S)-dihydroorotate+a quinoneorotate+a quinol
Catalysed by DHODH
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:30187CC BY 4.0Reference data