(R)-3-hydroxybutyric acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

296 compounds within 3 steps: 9 in 1, 64 in 2, 223 in 3

One step

2-hydroxybutyric acidReach from here →
1. transport of (R)-3-hydroxybutanoate (cytosol to extracellular)
Catalysed by SLC16A4, SLC16A5, SLC16A6, SLC16A3 and 2 moreextracellular space, cytosolOne of 2 routes
acetoacetateReach from here →
1. (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
Catalysed by BDH1, BDH2mitochondrial matrixOne of 4 routes
pyruvateReach from here →
1. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)
Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 2 moreextracellular space, cytosolOne of 2 routes
all-trans-retinoic acidReach from here →
1. transport of (R)-3-hydroxybutanoate and retinoate (cytosol to extracellular)
Catalysed by SLC16A4, SLC16A5, SLC16A8, SLC16A1extracellular space, cytosolOne of 2 routes
acetateReach from here →
1. transport of (R)-3-hydroxybutanoate and acetate (cytosol to extracellular)
Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1extracellular space, cytosolOne of 2 routes
formic acidReach from here →
1. transport of (R)-3-hydroxybutanoate and formate (cytosol to extracellular)
Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1extracellular space, cytosolOne of 2 routes
propionic acidReach from here →
1. transport of (R)-3-hydroxybutanoate and propanoate (cytosol to extracellular)
Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1extracellular space, cytosolOne of 2 routes
butyric acidReach from here →
1. transport of (R)-3-hydroxybutanoate and butyrate (cytosol to extracellular)
Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7extracellular space, cytosolOne of 2 routes
(S)-lactic acidReach from here →
1. transport of (R)-3-hydroxybutanoate and L-lactate (cytosol to extracellular)
Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosolOne of 2 routes

Two steps

(S)-3-hydroxybutanoateReach from here →
1. (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
2. (S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate
Catalysed by BDH1, BDH2, ADHFE1mitochondrial matrix
prostaglandin E3Reach from here →
1. transport of (R)-3-hydroxybutanoate and L-lactate (cytosol to extracellular)
2. Transport of Prostaglandin E3, Lactate Antiport
Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosol

One of 2 routes

prostaglandin A2Reach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosolOne of 2 routes

prostaglandin J2Reach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 1 moreextracellular space, cytosolOne of 2 routes

all-trans-4-hydroxyretinoateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A8, SLC16A1 and 1 moreextracellular space, cytosolOne of 3 routes

N-acetylcadaverineReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 1 moreextracellular space, cytosol

all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A8, SLC16A1 and 3 moreextracellular space, cytosol, endoplasmic reticulum

all-trans-18-hydroxyretinoateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A8, SLC16A1 and 25 moreextracellular space, cytosolOne of 2 routes

a phenyl acetateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 3 moreextracellular space, cytosol

CHEBI:15345Reach from here →

Catalysed by BDH1, BDH2, AACSmitochondrial matrix, cytosolOne of 3 routes

acetoneReach from here →

Catalysed by BDH1, BDH2mitochondrial matrix

acetylpyruvateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

propionyl-CoAReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 3 moreextracellular space, cytosolOne of 3 routes

(S)-malateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 1 moreextracellular space, cytosolOne of 2 routes

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol, mitochondrial matrix

oxaloacetateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

N(2)-acetyl-L-ornithineReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 1 moreextracellular space, cytosol

(S)-lactateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 7 moreextracellular space, cytosol

2-oxobutanoateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

2-oxoglutaramateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

ferrocytochrome cReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol, mitochondrial matrix

3-hydroxypyruvateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

17alpha-hydroxyprogesteroneReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 1 moreextracellular space, cytosol, endoplasmic reticulum

aceneuramateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

5'-deoxyadenosineReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol

4-methylumbelliferyl acetateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 3 moreextracellular space, cytosol

urateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 moreextracellular space, cytosol

all-trans-retinalReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A8, SLC16A1extracellular space, cytosol

4-fumarylacetoacetateReach from here →

Catalysed by BDH1, BDH2, FAHmitochondrial matrix

dTDPReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 4 moreextracellular space, cytosol

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

5-(3-methylguanidino)-2-oxopentanoateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

17alpha-hydroxypregnenoloneReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 1 moreextracellular space, cytosol, endoplasmic reticulum

chlorine(.)Reach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A1 and 1 moreextracellular space, cytosolOne of 2 routes

3-hydroxypyruvic acidReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

3-oxopropanoateReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol

D-serineReach from here →

Catalysed by SLC16A4, SLC16A5, SLC16A3, SLC16A7 and 3 moreextracellular space, cytosol