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Proteins/UNIPROT:P14174
Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity..
Function from UniProtKB (P14174), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
1,265 statements
1,265 statements · 7 reference databases · Subject: MIF · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
4 reactions
3-phenylpyruvateMAM00647c
Catalysed by MIF
Reaction pageLeft to rightBalancedEC 5.3.2.1cytosol
Human-GEM MAR06727CC BY 4.0Reference data
3-(4-hydroxyphenyl)pyruvateMAM00643c
Catalysed by MIF
Reaction pageLeft to rightBalancedEC 5.3.2.1cytosol
Human-GEM MAR06771CC BY 4.0Reference data
CHEBI:57509CHEBI:16875
Catalysed by MIF or
7 names
Resolves to: MIF
Reaction pageDirection not assertedBalanced
Rhea RHEA:13041CC BY 4.0Reference data
3-phenylpyruvateenol-phenylpyruvate
Catalysed by MIF
Reaction pageDirection not assertedBalanced
Rhea RHEA:17097CC BY 4.0Reference data