(S)-2-hydroxyglutarate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

157 compounds within 3 steps: 1 in 1, 58 in 2, 98 in 3

One step

AH2Reach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
Catalysed by L2HGDH

Two steps

(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)
Catalysed by L2HGDH, MOCS1
AReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
Catalysed by L2HGDH, AIFM1, PYROXD1One of 70 routes
(18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (18S)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + A + H2O
Catalysed by L2HGDH, PTGS2
(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + AH2 + O2 = (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate + A + H2O
Catalysed by L2HGDH, PTGS2
prostaglandin H3Reach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O
Catalysed by L2HGDH, PTGS2
13-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = 13-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by L2HGDH, PTGS2
9-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = 9-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by L2HGDH, PTGS2
(13R)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)-octadecadienoate + A + H2O
Catalysed by L2HGDH, PTGS1, PTGS2
2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by L2HGDH, PTGS2
2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by L2HGDH, PTGS2
2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + AH2 + O2 = 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + A + H2O
Catalysed by L2HGDH, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O
Catalysed by L2HGDH, PTGS2
2-(prostaglandin H2)-sn-glycero-3-phosphocholineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O
Catalysed by L2HGDH, PTGS2
cob(II)alaminReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2
Catalysed by L2HGDH, MTRR
iodideReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by L2HGDH, DIO1, DIO3One of 22 routes
nitric oxideReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O
Catalysed by L2HGDH, SUOX
3'-deoxy-3',4'-didehydro-CTPReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)
Catalysed by L2HGDH, RSAD2
5'-deoxyadenosineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by L2HGDH, CDK5RAP1One of 4 routes
3,3',5'-triiodo-L-thyronine sulfateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2
Catalysed by L2HGDH, DIO1
3,3'-diiodo-L-thyronineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2
Catalysed by L2HGDH, DIO1, DIO3One of 2 routes
3,3'-diiodo-L-thyronine sulfateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2
Catalysed by L2HGDH, DIO1One of 2 routes
3',5'-diiodo-L-thyronineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
Catalysed by L2HGDH, DIO3
3-iodothyronamineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2
Catalysed by L2HGDH, DIO1, DIO3One of 2 routes
3-iodo-L-thyronineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2
Catalysed by L2HGDH, DIO1, DIO3One of 2 routes
3'-iodo-L-thyronineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2
Catalysed by L2HGDH, DIO1, DIO2One of 2 routes
L-thyronineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2
Catalysed by L2HGDH, DIO3
thyronamineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2
Catalysed by L2HGDH, DIO3
3'-iodothyronamineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2
Catalysed by L2HGDH, DIO1, DIO2One of 2 routes
3,3'-diiodothyronamineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by L2HGDH, DIO1, DIO2One of 2 routes
3',5'-diiodothyronamineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2
Catalysed by L2HGDH, DIO3
3,3',5'-triiodothyronamineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2
Catalysed by L2HGDH, DIO3
hydrogenselenideReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by L2HGDH, SCLY
25-hydroxycholesterolReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Catalysed by L2HGDH, CH25H
all-trans-13,14-dihydroretinolReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
Catalysed by L2HGDH, RETSAT
3,3',5-triiodo-L-thyronineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by L2HGDH, DIO1, DIO2
3,3',5'-triiodo-L-thyronineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by L2HGDH, DIO1, DIO3
prostaglandin H2Reach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Catalysed by L2HGDH, PTGS1, PTGS2One of 2 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by L2HGDH, TBXAS1, PTGS2, PTGIS
L-methionineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by L2HGDH, CDK5RAP1One of 4 routes
L-alanineReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by L2HGDH, SCLYOne of 2 routes
a 2,3-saturated acyl-CoAReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2
Catalysed by L2HGDH, ACAD10
(9S)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by L2HGDH, PTGS1, PTGS2
(9R)-hydroxy-(10E,12Z)-octadecadienoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)-octadecadienoate + A + H2O
Catalysed by L2HGDH, PTGS1, PTGS2
(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by L2HGDH, PTGS2
(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by L2HGDH, PTGS2
thio-Mo-molybdopterinReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by L2HGDH, MOCOS
2-glyceryl-prostaglandin H2Reach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. 2-glyceryl-prostaglandin G2 + AH2 = 2-glyceryl-prostaglandin H2 + A + H2O
Catalysed by L2HGDH, PTGS2
prostaglandin H1Reach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by L2HGDH, PTGS2
(5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
1. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by L2HGDH, PTGS2