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Proteins/UNIPROT:Q96GD0
Functions as a pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP and therefore plays a role in vitamin B6 metabolism. Also functions as a protein serine phosphatase that specifically dephosphorylates 'Ser-3' in proteins of the actin-depolymerizing factor (ADF)/cofilin family like CFL1 and DSTN. Thereby, regulates cofilin-dependent actin cytoskeleton reorganization, being required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phosphothreonines in LIMK1. Does not dephosphorylate peptides containing phosphotyrosine..
Function from UniProtKB (Q96GD0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
53 statements
53 statements · 5 reference databases · Subject: PDXP · Sources: gene ontology, Hetionet, Human-GEM, Rhea, UniProt
7 reactions
water+CHEBI:18405phosphate(3-)+pyridoxal
Catalysed by SH3BP1 or PHOSPHO2 or KLHL23 or PDXP
Reaction pageLeft to rightBalancedEC 3.1.3.74cytosol
Human-GEM MAR04064CC BY 4.0Reference data
water+MAM02816cphosphate(3-)+MAM02815c
Catalysed by PHOSPHO2 or
5 names
Resolves to: PDXP
Reaction pageLeft to rightBalancedEC 3.1.3.74cytosol
Human-GEM MAR08724CC BY 4.0Reference data
water+pyridoxine 5'-phosphatephosphate(3-)+pyridoxine
Reaction pageLeft to rightBalancedEC 3.1.3.74cytosol
Human-GEM MAR08725CC BY 4.0Reference data
pyridoxal 5'-phosphate+waterpyridoxal+hydrogenphosphate
Catalysed by ALPL or PHOSPHO2 or PDXP
Reaction pageLeft to rightBalanced
Rhea RHEA:20533CC BY 4.0Reference data
O-phospho-L-seryl-[protein]+waterL-seryl-[protein]+hydrogenphosphate
Catalysed by PPP6C or CTDSP2 or PPEF1 or PPEF2 or CTDSPL or PPM1D or PPM1G or PHLPP1 or CDC14B or PPM1B or DUSP14 or EPM2A and 61 more alternatives
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:20629CC BY 4.0Reference data
pyridoxine 5'-phosphate+waterpyridoxine+hydrogenphosphate
Catalysed by PDXP
Reaction pageLeft to rightBalanced
Rhea RHEA:25112CC BY 4.0Reference data
CHEBI:57761+hydrogenphosphateCHEBI:58451+water
Catalysed by PDXP
Reaction pageRight to leftBalanced
Rhea RHEA:25135CC BY 4.0Reference data