What it touches on the way
Mechanistic reach
5 entities
5 entities reached.
0 reported hops5 assembled from the scaffold
- RDH5ProteinUNIPROT:Q92781substrate ofInferred only32 paths16 endpoints
- RDH16ProteinUNIPROT:O75452substrate ofInferred only14 paths7 endpoints
- DHRS4ProteinUNIPROT:Q9BTZ2substrate ofInferred only14 paths7 endpoints
- HSD17B6ProteinUNIPROT:O14756substrate ofInferred only8 paths4 endpoints
- RLBP1ProteinUNIPROT:P12271substrate ofInferred only2 paths1 endpoint
What the reference databases state
Statements
19 statements
19 statements · 1 reference database · Subject: 11-cis-retinal · Sources: Human-GEM
- 11-cis-retinol is converted to 11-cis-retinalCompoundHuman-GEM MAR08709Inferred only
- 11-cis-retinal is converted to 11-cis-retinolCompoundHuman-GEM MAR08709Inferred only
- 11-cis-retinol is converted to 11-cis-retinalCompoundHuman-GEM MAR06638Inferred only
- 11-cis-retinal is converted to 11-cis-retinolCompoundHuman-GEM MAR06638Inferred only
- all-trans-retinal is converted to 11-cis-retinalCompoundHuman-GEM MAR06651Inferred only
- 11-cis-retinal is a substrate of DHRS4ProteinHuman-GEM MAR06638Inferred only
- 11-cis-retinal is a substrate of DHRS4ProteinHuman-GEM MAR08709Inferred only
- 11-cis-retinal is a substrate of DHRS4L2ProteinHuman-GEM MAR08709Inferred only
- 11-cis-retinal is a substrate of DHRS4L2ProteinHuman-GEM MAR06638Inferred only
- 11-cis-retinal is a substrate of HSD17B6ProteinHuman-GEM MAR06638Inferred only
- 11-cis-retinal is a substrate of HSD17B6ProteinHuman-GEM MAR08709Inferred only
- 11-cis-retinal is a substrate of RBP3ProteinHuman-GEM MAR08709Inferred only
Show the remaining 7
- 11-cis-retinal is a substrate of RBP3ProteinHuman-GEM MAR06638Inferred only
- 11-cis-retinal is a substrate of RDH16ProteinHuman-GEM MAR06638Inferred only
- 11-cis-retinal is a substrate of RDH16ProteinHuman-GEM MAR08709Inferred only
- 11-cis-retinal is a substrate of RDH5ProteinHuman-GEM MAR08709Inferred only
- 11-cis-retinal is a substrate of RDH5ProteinHuman-GEM MAR06638Inferred only
- 11-cis-retinal is a substrate of RLBP1ProteinHuman-GEM MAR06638Inferred only
- 11-cis-retinal is a substrate of RLBP1ProteinHuman-GEM MAR08709Inferred only
Reactions
7 reactions
11-cis-retinal+proton+NADPH(4-)+dioxygenMAM01023c+water+NADP(3-)
Reaction pageLeft to rightBalancedEC 2.5.1.18GO:0005829
Human-GEM MAR02960CC BY 4.0Reference data
11-cis-retinal+proton+NADH(2-)11-cis-retinol+NAD(+)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or DHRS4L2 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105GO:0005829
Human-GEM MAR06638CC BY 4.0Reference data
all-trans-retinal11-cis-retinal
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR06651CC BY 4.0Reference data
11-cis-retinal+proton+NADPH(4-)11-cis-retinol+NADP(3-)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or DHRS4L2 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105GO:0005829
Human-GEM MAR08709CC BY 4.0Reference data
11-cis-retinol+NAD(1-)11-cis-retinal+NADH(2-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:42060CC BY 4.0Reference data
11-cis-retinal+NAD(1-)+waterCHEBI:87435+NADH(2-)+2hydron
Catalysed by ALDH1A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:47132CC BY 4.0Reference data
11-cis-retinol+NADP(3-)11-cis-retinal+NADPH(4-)+hydron
Catalysed by RDH11 or RDH12 or RDH14
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:54912CC BY 4.0Reference data