malonic acid

Three steps

• L-homoarginineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by SLC6A14, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homocarnosineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and histidine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by SLC6A14, CARNS1extracellular space, cytosolOne of 3 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by SLC6A9, SLC6A14, GARTextracellular space, cytosol

• L-cystine-bis-glycineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by SLC6A9, SLC6A14, DPEP1, DPEP2extracellular space, cytosol

• indoxyl sulfateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. indoxyl sulfate(out) + a dicarboxylate(in) = indoxyl sulfate(in) + a dicarboxylate(out)

  Catalysed by SLC25A10, SLC25A35, SLC25A34, SLC22A6 and 1 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycyldehydrophenylalanineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by SLC6A9, SLC6A14, DPEP1extracellular space, cytosol

• S-adenosylglutathioneReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by SLC25A10, TSTD1, MMACHCmitochondrial matrix, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Glutamine by Atb0 Transporter
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by SLC6A14, PFASextracellular space, cytosol

• kinetensinReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Chymase

  Catalysed by SLC6A14, CMA1extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by SLC6A9, SLC6A14, GLYATL2extracellular space, cytosol

• acetaldehydeReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Threonine by Atb0 Transporter
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by SLC6A14extracellular space, cytosol

• acetylcholineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and choline (cytosol to extracellular)
  3. Acetyl-CoA:choline O-acetyltransferase

  Catalysed by SLC5A7, CHATextracellular space, cytosolOne of 3 routes

• acetylpyruvateReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by SLC25A10, MPST, TST, FAHD1mitochondrial matrix, cytosol

• all-trans-retinoic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by SLC25A10, MPST, TST, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)

  Catalysed by SLC6A14, PAHextracellular space, cytosolOne of 3 routes

• CHEBI:15477Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. 2-Methylbutyrylglycine Transport, Extracellular
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLC6A5, GLYAT, GLYATL2, GLYATL1extracellular space, cytosol, mitochondrial matrix

• propionyl-CoAReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. Active Transport

  Catalysed by SLC6A14extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• CHEBI:15570Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC3A2, SLC7A10extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by SLC6A9, SLC6A14, GNMTextracellular space, cytosol

• 10-formyltetrahydrofolic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and formate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by SLC26A4, MTHFD1extracellular space, cytosolOne of 2 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

  Catalysed by SLC6A14, PAHextracellular space, cytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of glycine and homoserine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC7A5extracellular space, cytosolOne of 52 routes

• betaine aldehydeReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and choline (cytosol to extracellular)
  3. choline dehydrogenase (choline)

  Catalysed by SLC5A7, CHDHextracellular space, cytosolOne of 3 routes

• trimethylenediamineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and lysine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by SLC6A14, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and histidine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by SLC6A14, CARNS1extracellular space, cytosolOne of 2 routes

• formateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by SLC25A10, SLC25A14, SLC26A2, SLC25A30 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• hexadecanoic acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by SLC25A10, SLC22A6, QPRTmitochondrial matrix, cytosol, extracellular space

• CHEBI:15765Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Tyrosine by Atb0 Transporter
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by SLC6A14, THextracellular space, cytosolOne of 5 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SLC25A10, SLC25A14, SLC25A30, CADmitochondrial matrix, cytosol, inner side of the membrane, outer side of the membrane

• alpha-D-glucosamine 6-phosphateReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Glutamine by Atb0 Transporter
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by SLC6A14, GFPT2, GFPT1extracellular space, cytosol

• ferricytochrome cReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. sulfite:ferricytochrome-c oxidoreductase
  3. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion

  Catalysed by SLC25A10, SUOXmitochondrial matrix, cytosolOne of 4 routes

• androsteroneReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SLC25A10, STSmitochondrial matrix, cytosolOne of 3 routes

• a halide anionReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SLC25A10, TSTD1, GSTT4, GSTA4 and 21 moremitochondrial matrix, cytosol

• ureaReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by SLC6A14, ARG1extracellular space, cytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. transport of malonate and sulfite (cytosol to mitochondria)
  2. 3-mercaptopyruvate:sulfide sulfurtransferase
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC25A10, MPST, TST, AGXT2mitochondrial matrix, cytosol

• succinic semialdehydeReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)
  3. 4-aminobutanoate:2-oxoglutarate aminotransferase

  Catalysed by SLC6A12, ABATextracellular space, cytosol, mitochondrial matrix

• L-cystineReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

  Catalysed by SLC25A10, SLC25A14, SLC25A30, SLC7A13mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 9 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of alanine and chloride (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC6A14, AGXT2extracellular space, cytosol, mitochondrial matrix

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SLC25A10, STSmitochondrial matrix, cytosolOne of 3 routes

• (R)-carnitineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of betaine and chloride (cytosol to extracellular)
  3. glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

  Catalysed by SLC6A12, SLC22A5extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-citrullineReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of citrulline and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC7A9, SLC3A1 and 1 moreextracellular space, cytosolOne of 39 routes

• ubiquinonesReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by SLC25A10, SDHD, SDHB, SDHA and 1 moremitochondrial matrix, cytosol

• oxaloacetateReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. transport of malate and OAA (cytosol to mitochondria)

  Catalysed by SLC25A10mitochondrial matrix, cytosolOne of 14 routes

• nitric oxideReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of arginine and chloride (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by SLC6A14, NOS3, NOS1, NOS2extracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. Malonate Transport, Antiport with Chloride
  2. transport of chloride and glycine (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• protein polypeptide chainReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. PROTEIN_BS

  Catalysed by SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 18 routes

• 2-phenylacetamideReach from here →
  1. Malonate Transport, Antiport with Chloride
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by SLC6A14, EPXextracellular space, cytosol

• pregnenoloneReach from here →
  1. transport of malonate and sulfate (cytosol to mitochondria)
  2. Steryl-Sulfatase
  3. Pregnenolone-sulfate sulfohydrolase

  Catalysed by SLC25A10, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 4 routes