Compound
4a-hydroxytetrahydrobiopterin
A tetrahydropterin that is 5,6,7,8-tetrahydrobiopterin carrying an additional hydroxy substituent at the 4a-position.
Definition from ChEBI (CHEBI:15374), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Chemical structure
- 4a-hydroxytetrahydrobiopterin has the functional parent 5,6,7,8-tetrahydrobiopterinCompoundChEBI CHEBI:15374Inferred only
Statements
10 statements
10 statements · 1 reference database · Subject: 4a-hydroxytetrahydrobiopterin · Sources: Human-GEM
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD1ProteinHuman-GEM MAR04543Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD1ProteinHuman-GEM MAR04540Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD1ProteinHuman-GEM MAR04544Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD1ProteinHuman-GEM MAR04539Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD1ProteinHuman-GEM MAR08538Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD2ProteinHuman-GEM MAR04539Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD2ProteinHuman-GEM MAR04540Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD2ProteinHuman-GEM MAR04543Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD2ProteinHuman-GEM MAR04544Inferred only
- 4a-hydroxytetrahydrobiopterin is a substrate of PCBD2ProteinHuman-GEM MAR08538Inferred only
Reactions
9 reactions
dioxygen+5,6,7,8-tetrahydrobiopterin+L-tryptophan4a-hydroxytetrahydrobiopterin+5-hydroxytryptophan
Reaction pageLeft to rightBalancedEC 1.14.16.4GO:0005829
Human-GEM MAR04537CC BY 4.0Reference data
4a-hydroxytetrahydrobiopterin4a-hydroxytetrahydrobiopterin
Reaction pageReversibleBalancedGO:0005829, GO:0005634
Human-GEM MAR04538CC BY 4.0Reference data
4a-hydroxytetrahydrobiopterinwater+MAM02632c
Reaction pageReversibleBalancedEC 4.2.1.96GO:0005829
Human-GEM MAR04539CC BY 4.0Reference data
4a-hydroxytetrahydrobiopterinwater+MAM02632n
Reaction pageReversibleBalancedEC 4.2.1.96GO:0005634
Human-GEM MAR04540CC BY 4.0Reference data
4a-hydroxytetrahydrobiopterinwater+MAM02823c
Reaction pageReversibleBalancedEC 4.2.1.96GO:0005829
Human-GEM MAR04543CC BY 4.0Reference data
4a-hydroxytetrahydrobiopterinwater+MAM02823n
Reaction pageReversibleBalancedEC 4.2.1.96GO:0005634
Human-GEM MAR04544CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+CHEBI:178954a-hydroxytetrahydrobiopterin+CHEBI:15765
Catalysed by TH
Reaction pageLeft to rightBalancedEC 1.14.16.2GO:0005829
Human-GEM MAR08537CC BY 4.0Reference data
4a-hydroxytetrahydrobiopterinMAM01698c+water
Reaction pageLeft to rightBalancedEC 4.2.1.96GO:0005829
Human-GEM MAR08538CC BY 4.0Reference data
dioxygen+L-phenylalanine+5,6,7,8-tetrahydrobiopterin4a-hydroxytetrahydrobiopterin+CHEBI:17895
Catalysed by PAH
Reaction pageLeft to rightBalancedEC 1.14.16.1GO:0005829
Human-GEM MAR08539CC BY 4.0Reference data
Other names
2 names
Resolves to: 4a-hydroxytetrahydrobiopterin
- Also called
- 4a-Hydroxy-5,6,4,8-tetrahydrobiopterin
- Systematic name
- 2-amino-6-(1,2-dihydroxypropyl)-4a-hydroxy-5,6,7,8-tetrahydropteridin-4(4aH)-one