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Proteins/UNIPROT:P16444

DPEP1

Protein·UNIPROT:P16444Dipeptidase 12 compounds

Open in the graph

Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Also possesses beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem..

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Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver..

Function from UniProtKB (P16444), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 2 · substrate of

Inferred

Assembled routes, not reported.

What routes through it

2 compounds

2 compounds.

0 reported routes2 assembled routes

glycineCompoundCHEBI:57305Inferred only44 paths22 endpoints
L-cystineCompound

What the reference databases state

Statements

43 statements

43 statements · 9 reference databases · Subject: DPEP1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways

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DPEP1 is expressed in adult mammalian kidneyAnatomyBgee ENSG00000015413Inferred only
DPEP1 is expressed in body of pancreasAnatomyBgee ENSG00000015413Inferred only
DPEP1 is expressed in colonAnatomyHuman Protein Atlas ENSG00000015413Inferred only
DPEP1 is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000015413Inferred only
DPEP1 is expressed in ileal mucosaAnatomyBgee ENSG00000015413Inferred only
DPEP1 is expressed in pancreasAnatomyHuman Protein Atlas ENSG00000015413Inferred only
DPEP1 is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000015413Inferred only
DPEP1 is expressed in testisAnatomyHuman Protein Atlas ENSG00000015413Inferred only
DPEP1 interacts with KIFBPProteinHetionet hetionet:interacts:1800-26128Inferred only
DPEP1 participates in Aflatoxin activation and detoxificationPathwayReactome R-HSA-5423646Inferred only
DPEP1 participates in Anti-inflammatory response favouring Leishmania parasite infectionPathwayReactome R-HSA-9662851Inferred only
DPEP1 participates in Arachidonate metabolismPathwayReactome R-HSA-2142753Inferred only

Show the remaining 31

DPEP1 participates in Biological oxidationsPathwayReactome R-HSA-211859Inferred only
DPEP1 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
DPEP1 participates in Eicosanoid metabolism via lipooxygenases LOX PathwayWikiPathways WP4721Inferred only
DPEP1 participates in Eicosanoid synthesisPathwayWikiPathways WP167Inferred only
DPEP1 participates in Fatty acid metabolismPathwayReactome R-HSA-8978868Inferred only
DPEP1 participates in GABA metabolism aka GHB PathwayWikiPathways WP4157Inferred only
DPEP1 participates in Gamma glutamyl cycle for the biosynthesis and degradation of glutathionePathwayWikiPathways WP4518Inferred only
DPEP1 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
DPEP1 participates in Leishmania infectionPathwayReactome R-HSA-9658195Inferred only
DPEP1 participates in Leishmania parasite growth and survivalPathwayReactome R-HSA-9664433Inferred only
DPEP1 participates in Leukotriene metabolic pathwayPathwayWikiPathways WP5171Inferred only
DPEP1 participates in LTC4-CYSLTR mediated IL4 productionPathwayReactome R-HSA-9664535Inferred only
DPEP1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
DPEP1 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
DPEP1 participates in Omega 3 fatty acids in senescencePathwayWikiPathways WP5432Inferred only
DPEP1 participates in Omega 6 fatty acids in senescencePathwayWikiPathways WP5424Inferred only
DPEP1 participates in Parasitic Infection PathwaysPathwayReactome R-HSA-9824443Inferred only
DPEP1 participates in Synthesis of Leukotrienes (LT) and Eoxins (EX)PathwayReactome R-HSA-2142691Inferred only
DPEP1 regulates negative regulation of cell migrationBiological processgene ontology P16444|GO:0030336Inferred only
DPEP1 requires the cofactor Zn(2+)CompoundUniProt P16444Inferred only
2,3-didehydrophenylalanine is a substrate of DPEP1CompoundRhea RHEA:62704Inferred only
an L-alpha-amino acid is a substrate of DPEP1CompoundRhea RHEA:48940Inferred only
an L-aminoacyl-L-amino acid is a substrate of DPEP1CompoundRhea RHEA:48940Inferred only
CHEBI:28666 is a substrate of DPEP1CompoundHuman-GEM MAR01085Inferred only
glycine is a substrate of DPEP1CompoundRhea RHEA:60520Inferred only
glycine is a substrate of DPEP1CompoundRhea RHEA:62704Inferred only
glycyl-L-leucine is a substrate of DPEP1CompoundHuman-GEM MAR11411Inferred only
glycyldehydrophenylalanine is a substrate of DPEP1CompoundRhea RHEA:62704Inferred only
L-cystine is a substrate of DPEP1CompoundRhea RHEA:60520Inferred only
L-cystine-bis-glycine is a substrate of DPEP1CompoundRhea RHEA:60520Inferred only
leukotriene D4 is a substrate of DPEP1CompoundRhea RHEA:48616Inferred only

Reactions

7 reactions

water+CHEBI:28666glycine+CHEBI:15650
Catalysed by DPEP1 or DPEP2
Reaction pageLeft to rightBalancedEC 3.4.13.19extracellular space
Human-GEM MAR01085CC BY 4.0Reference data
water+glycyl-L-leucineglycine+L-leucine
Catalysed by DPEP1 or CNDP2
Reaction page

Other names

7 names

Resolves to: DPEP1

Also called: Beta-lactamaseDehydropeptidase-IhRDPMDPMicrosomal dipeptidaseRDPRenal dipeptidase

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CHEBI:16283

Inferred only22 paths22 endpoints

Left to right

Balanced

EC 3.4.13.-

cytosol

Human-GEM MAR11411CC BY 4.0Reference data

CHEBI:35627+waterCHEBI:140347

Catalysed by DPEP1 or MBLAC2 or DCLRE1A or DCLRE1B

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:20401CC BY 4.0Reference data

leukotriene D4+waterleukotriene E4+glycine

Catalysed by DPEP1 or DPEP2

Reaction pageLeft to rightBalanced

Rhea RHEA:48616CC BY 4.0Reference data

an L-aminoacyl-L-amino acid+water2an L-alpha-amino acid

Catalysed by DPEP1 or DPEP2

Reaction pageDirection not assertedBalance undeterminable

Rhea RHEA:48940CC BY 4.0Reference data

L-cystine-bis-glycine+2waterL-cystine+2glycine

Catalysed by DPEP1 or DPEP2

Reaction pageDirection not assertedBalanced

Rhea RHEA:60520CC BY 4.0Reference data

glycyldehydrophenylalanine+water2,3-didehydrophenylalanine+glycine

Catalysed by DPEP1

Reaction pageDirection not assertedBalanced

Rhea RHEA:62704CC BY 4.0Reference data