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© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P28329

CHAT

Protein·UNIPROT:P28329Choline O-acetyltransferase1 compound

Open in the graph

Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses..

Function from UniProtKB (P28329), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 1 · substrate of

Inferred

Assembled routes, not reported.

What routes through it

1 compound

1 compound.

0 reported routes1 assembled route

cholineCompoundCHEBI:15354Inferred only60 paths20 endpoints

What the reference databases state

GenCC submitters' classifications

1 row

congenital myasthenic syndrome 6 has a germline basis in CHATDiseaseGenCC HGNC:1912|MONDO:0009689Inferred only

Statements

36 statements

36 statements · 6 reference databases · Subject: CHAT · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways

Search this listOrder

CHAT covaries with SPOCD1ProteinHetionet hetionet:covaries:1103-90853Inferred only
ZNF177 covaries with CHATProteinHetionet hetionet:covaries:1103-7730Inferred only
CHAT is expressed in caudate nucleusAnatomyHuman Protein Atlas ENSG00000070748Inferred only
CHAT is expressed in colonAnatomyHuman Protein Atlas ENSG00000070748Inferred only
CHAT is expressed in duodenumAnatomyHuman Protein Atlas ENSG00000070748Inferred only
CHAT is expressed in rectumAnatomyHuman Protein Atlas ENSG00000070748Inferred only
CHAT is expressed in Small intestineAnatomyHuman Protein Atlas ENSG00000070748Inferred only
CHAT is expressed in vermiform appendixAnatomyHuman Protein Atlas ENSG00000070748Inferred only
CAMK2A interacts with CHATProteinHetionet hetionet:interacts:1103-815Inferred only
CAMK2G interacts with CHATProteinHetionet hetionet:interacts:1103-818Inferred only
CHAT interacts with NEDD9ProteinHetionet hetionet:interacts:1103-4739Inferred only
CHAT interacts with PRKCAProteinHetionet hetionet:interacts:1103-5578Inferred only

Show the remaining 24

CHAT interacts with PRKCBProteinHetionet hetionet:interacts:1103-5579Inferred only
CHAT interacts with PRKCEProteinHetionet hetionet:interacts:1103-5581Inferred only
CHAT interacts with PRKCGProteinHetionet hetionet:interacts:1103-5582Inferred only
CHAT interacts with PRKCZProteinHetionet hetionet:interacts:1103-5590Inferred only
CHAT participates in 10q11 21q11 23 copy number variation syndromePathwayWikiPathways WP5352Inferred only
CHAT participates in Acetylcholine Neurotransmitter Release CyclePathwayReactome R-HSA-264642Inferred only
CHAT participates in Acetylcholine synthesisPathwayWikiPathways WP528Inferred only
CHAT participates in Biogenic amine synthesisPathwayWikiPathways WP550Inferred only
CHAT participates in Cell lineage map for neuronal differentiationPathwayWikiPathways WP5417Inferred only
CHAT participates in Glycerophospholipid biosynthesisPathwayReactome R-HSA-1483206Inferred only
CHAT participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
CHAT participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
CHAT participates in Neuronal SystemPathwayReactome R-HSA-112316Inferred only
CHAT participates in Neurotransmitter release cyclePathwayReactome R-HSA-112310Inferred only
CHAT participates in Phospholipid metabolismPathwayReactome R-HSA-1483257Inferred only
CHAT participates in Sudden infant death syndrome SIDS susceptibility pathwaysPathwayWikiPathways WP706Inferred only
CHAT participates in Synthesis of PCPathwayReactome R-HSA-1483191Inferred only
CHAT participates in Transmission across Chemical SynapsesPathwayReactome R-HSA-112315Inferred only
acetylcholine is a substrate of CHATCompoundRhea RHEA:18821Inferred only
acetylcholine is a substrate of CHATCompoundHuman-GEM MAR08362Inferred only
CHEBI:1146900 is a substrate of CHATCompoundHuman-GEM MAR08362Inferred only
choline is a substrate of CHATCompoundHuman-GEM MAR00640Inferred only
choline is a substrate of CHATCompoundRhea RHEA:18821Inferred only
choline is a substrate of CHATCompoundHuman-GEM MAR08362Inferred only

Reactions

3 reactions

CHEBI:15351+cholineacetylcholine+CHEBI:1146900
Catalysed by CHAT
Reaction pageLeft to rightBalancedEC 2.3.1.6cytosol
Human-GEM MAR00640CC BY 4.0Reference data
acetylcholine+CHEBI:1146900CHEBI:15351+choline
Catalysed by CHAT
Reaction pageReversibleBalancedEC 2.3.1.6nucleus
Human-GEM MAR08362

Other names

2 names

Resolves to: CHAT

Also called: CHOACTaseCholine acetylase

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CC BY 4.0

Reference data

choline+acetyl-CoAacetylcholine+coenzyme A(4-)

Catalysed by CHAT

Reaction pageDirection not assertedBalanced

Rhea RHEA:18821CC BY 4.0Reference data