oxaloacetate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

778 compounds within 3 steps: 9 in 1, 191 in 2, 578 in 3

One step

CHEBI:1146900Reach from here →
1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Catalysed by CSmitochondrial matrixOne of 2 routes
pyruvateReach from here →
1. Oxaloacetate Decarboxylase
Catalysed by FAHD1cytosolOne of 4 routes
(S)-malateReach from here →
1. transport of malate and OAA (cytosol to mitochondria)
No catalyst recordedmitochondrial matrix, cytosolOne of 5 routes
5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
1. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate
Catalysed by AGXT2
L-aspartateReach from here →
1. L-Aspartate:2-oxoglutarate aminotransferase
Catalysed by GOT2mitochondrial matrixOne of 5 routes
citric acidReach from here →
1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Catalysed by CSmitochondrial matrixOne of 2 routes
4-hydroxy-2-oxoglutaric acidReach from here →
1. D-aspartate:2-oxoglutarate aminotransferase
Catalysed by GOT2mitochondrial matrix
phosphoenolpyruvic acidReach from here →
1. GTP:oxaloacetate carboxy-lyase (adding GTP
Catalysed by PCK1cytosolOne of 2 routes
phosphoenolpyruvateReach from here →
1. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2
Catalysed by PCK1, PCK2

Two steps

(S)-carnitineReach from here →
1. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
2. Carnitine O-Palmitoyltransferase
Catalysed by CS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 244 routes
2-hydroxybutyric acidReach from here →
1. Oxaloacetate Decarboxylase
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)
Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 more

cytosol, extracellular space

One of 2 routes

acetoacetateReach from here →

Catalysed by FAHD1cytosol, mitochondrial matrixOne of 4 routes

(7Z)-octadecenoyl-CoAReach from here →

Catalysed by CS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 3 routes

CHEBI:15345Reach from here →

Catalysed by CS, AACSmitochondrial matrix, cytosolOne of 2 routes

cholineReach from here →

Catalysed by CS, CHATmitochondrial matrix, nucleus

acetylpyruvateReach from here →

Catalysed by FAHD1cytosol

all-trans-retinoic acidReach from here →

Catalysed by FAHD1, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

CHEBI:15380Reach from here →

Catalysed by CS, ALAS1, CPNE7mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Catalysed by CS, GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Catalysed by CS, CPT1A, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

isobutyryl-CoAReach from here →

Catalysed by CS, HADHA, ACAA2, HADHBmitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Catalysed by CS, GLYATmitochondrial matrix

isovaleryl-CoAReach from here →

Catalysed by CS, GLYAT, GLYATL2, GLYATL1mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

CHEBI:15519Reach from here →

Catalysed by CS, ACAA1, SCP2, MYO5Bmitochondrial matrix, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

Catalysed by CS, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

oleoyl-CoAReach from here →

Catalysed by CS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 11 routes

phenylacetyl-CoAReach from here →

Catalysed by CSmitochondrial matrix, cytosolOne of 3 routes

propionyl-CoAReach from here →

Catalysed by CS, ACSS3, ACSS2, ACSS1mitochondrial matrix, cytosolOne of 43 routes

D-threo-isocitrateReach from here →

Catalysed by CS, ACO1, ACO2mitochondrial matrixOne of 3 routes

L-leucineReach from here →

Catalysed by GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

CHEBI:15650Reach from here →

Catalysed by CS, ZDHHC11B, NAA10, ESCO2 and 29 moremitochondrial matrix, cytosolOne of 2 routes

trans-aconitateReach from here →

Catalysed by CS, SLC25A1mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

CHEBI:15727Reach from here →

Catalysed by CS, NAA10mitochondrial matrix, cytosol

CHEBI:15746Reach from here →

Catalysed by CS, SAT1, SAT2mitochondrial matrix, cytosolOne of 2 routes

malonateReach from here →

Catalysed by SLC25A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

N-carbamoyl-L-aspartic acidReach from here →

Catalysed by GOT2, CADmitochondrial matrix, cytosol

sulfateReach from here →

Catalysed by GOT2, SLC25A14, SLC25A30mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by FAHD1, AGXT2cytosol, mitochondrial matrix

L-cystineReach from here →

Catalysed by GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

CHEBI:16284Reach from here →

Catalysed by PCK1, PKM, PKLRcytosol

11-cis-retinolReach from here →

Catalysed by CS, DGAT1, LRAT, AWAT1 and 2 moremitochondrial matrix, cytosol

cis-aconitateReach from here →

Catalysed by CS, SLC25A1mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

L-valineReach from here →

Catalysed by GOT2, SLC7A13mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

CHEBI:16497Reach from here →

Catalysed by PCK1, PKM, PKLRcytosol

protein polypeptide chainReach from here →

Catalysed by GOT2mitochondrial matrix, cytosol

(S)-lactateReach from here →

Catalysed by FAHD1, LDHA, LDHB, LDHC and 2 morecytosol

2-oxobutanoateReach from here →

Catalysed by FAHD1, AGXT2cytosolOne of 2 routes

2-oxoglutaramateReach from here →

Catalysed by FAHD1, KYAT1cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by FAHD1cytosol