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Proteins/UNIPROT:P31040
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor..
Function from UniProtKB (P31040), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
8 rows
387 statements
387 statements · 8 reference databases · Subject: SDHA · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways · Rows fetched: 300
4 reactions
fumaric acid+ubiquinolsuccinate(2-)+ubiquinones
Catalysed by SDHD & SDHB & SDHA & SDHC
Reaction pageReversibleBalancedEC 1.3.5.1mitochondrial matrix
Human-GEM MAR04652CC BY 4.0Reference data
a ubiquinone+succinate(2-)a ubiquinol+fumaric acid
Catalysed by SDHA
1 paper
5 names
Resolves to: SDHA
Rhea RHEA:13713CC BY 4.0Reference data
(R)-malate+a quinoneenol-oxaloacetate+a quinol
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:79827CC BY 4.0Reference data
(S)-malate+a quinoneenol-oxaloacetate+a quinol
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:79831CC BY 4.0Reference data