Loading the page.
Proteins/UNIPROT:Q9H4A9
Dipeptidase that hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4). Hydrolyzes cystinyl-bis-glycine..
Independently of its dipeptidase activity can also modulate macrophage inflammatory response by acting as a regulator of NF-kappaB inflammatory signaling pathway..
Function from UniProtKB (Q9H4A9), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
29 statements
29 statements · 6 reference databases · Subject: DPEP2 · Sources: Bgee, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
4 reactions
water+CHEBI:28666glycine+CHEBI:15650
Reaction pageLeft to rightBalancedEC 3.4.13.19extracellular space
Human-GEM MAR01085CC BY 4.0Reference data
1 name
Resolves to: DPEP2
Rhea RHEA:48616CC BY 4.0Reference data
an L-aminoacyl-L-amino acid+water2an L-alpha-amino acid
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48940CC BY 4.0Reference data
L-cystine-bis-glycine+2waterL-cystine+2glycine
Reaction pageDirection not assertedBalanced
Rhea RHEA:60520CC BY 4.0Reference data