Compound
acetaldehyde
A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C2H4O
- Mass
- 44.053 g/mol
- Charge
- 0
- InChIKey
- IKHGUXGNUITLKF-UHFFFAOYSA-N
- SMILES
- [H]C(C)=O
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
12 entities
12 entities reached.
0 reported hops12 assembled from the scaffold
- ALDH2ProteinUNIPROT:P05091metabolized byInferred only32 paths32 endpoints
- ALDH1A1ProteinUNIPROT:P00352metabolized byInferred only31 paths31 endpoints
- ALDH1B1ProteinUNIPROT:P30837metabolized byInferred only22 paths11 endpoints
- ALDH3B1ProteinUNIPROT:P43353metabolized byInferred only18 paths9 endpoints
- ALDH3A1ProteinUNIPROT:P30838metabolized byInferred only16 paths8 endpoints
- ALDH1A3ProteinUNIPROT:P47895metabolized byInferred only15 paths15 endpoints
- DERAProteinUNIPROT:Q9Y315substrate ofInferred only14 paths7 endpoints
- ALDH9A1ProteinUNIPROT:P49189metabolized byInferred only14 paths7 endpoints
- ALDH3A2ProteinUNIPROT:P51648metabolized byInferred only14 paths14 endpoints
- ALDH7A1ProteinUNIPROT:P49419metabolized byInferred only13 paths13 endpoints
- ALDH3B2ProteinUNIPROT:P48448metabolized byInferred only10 paths5 endpoints
- ETNPPLProteinUNIPROT:Q8TBG4substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
39 statements
39 statements · 2 reference databases · Subject: acetaldehyde · Sources: Human-GEM, Rhea
- acetaldehyde is converted to 3-oxopropanoateCompoundRhea RHEA:45160Inferred only
- 3-oxopropanoate is converted to acetaldehydeCompoundRhea RHEA:45160Inferred only
- acetaldehyde is converted to acetateCompoundHuman-GEM MAR04283Inferred only
- acetaldehyde is converted to acetateCompoundHuman-GEM MAR01568Inferred only
- acetate is converted to acetaldehydeCompoundRhea RHEA:25298Inferred only
- acetaldehyde is converted to acetateCompoundRhea RHEA:25294Inferred only
- acetaldehyde is converted to acetateCompoundRhea RHEA:25298Inferred only
- acetaldehyde is converted to acetateCompoundHuman-GEM MAR08357Inferred only
- ethanol is converted to acetaldehydeCompoundRhea RHEA:25290Inferred only
- ethanol is converted to acetaldehydeCompoundHuman-GEM MAR03905Inferred only
- ethanol is converted to acetaldehydeCompoundHuman-GEM MAR03907Inferred only
- ethanol is converted to acetaldehydeCompoundHuman-GEM MAR08360Inferred only
Show the remaining 27
- ethanol is converted to acetaldehydeCompoundHuman-GEM MAR08757Inferred only
- ethanolamine is converted to acetaldehydeCompoundHuman-GEM MAR00647Inferred only
- ethanolamine is converted to acetaldehydeCompoundRhea RHEA:15313Inferred only
- acetaldehyde is converted to ethanolamineCompoundRhea RHEA:15313Inferred only
- O-phosphoethanolamine is converted to acetaldehydeCompoundHuman-GEM MAR04296Inferred only
- acetaldehyde is converted to phosphoethanolamineCompoundRhea RHEA:17889Inferred only
- phosphoethanolamine is converted to acetaldehydeCompoundRhea RHEA:17889Inferred only
- acetaldehyde is converted to pyruvateCompoundRhea RHEA:45484Inferred only
- pyruvate is converted to acetaldehydeCompoundRhea RHEA:45484Inferred only
- acetaldehyde is metabolised by ALDH1A1ProteinRhea RHEA:25294Inferred only
- acetaldehyde is metabolised by ALDH1A3ProteinHuman-GEM MAR01568Inferred only
- acetaldehyde is metabolised by ALDH1B1ProteinRhea RHEA:25294Inferred only
- acetaldehyde is metabolised by ALDH1B1ProteinHuman-GEM MAR08357Inferred only
- acetaldehyde is metabolised by ALDH2ProteinHuman-GEM MAR08357Inferred only
- acetaldehyde is metabolised by ALDH3A1ProteinHuman-GEM MAR01568Inferred only
- acetaldehyde is metabolised by ALDH3A1ProteinHuman-GEM MAR04283Inferred only
- acetaldehyde is metabolised by ALDH3A2ProteinHuman-GEM MAR08357Inferred only
- acetaldehyde is metabolised by ALDH3B1ProteinHuman-GEM MAR04283Inferred only
- acetaldehyde is metabolised by ALDH3B1ProteinHuman-GEM MAR01568Inferred only
- acetaldehyde is metabolised by ALDH3B2ProteinHuman-GEM MAR01568Inferred only
- acetaldehyde is metabolised by ALDH3B2ProteinHuman-GEM MAR04283Inferred only
- acetaldehyde is metabolised by ALDH7A1ProteinHuman-GEM MAR08357Inferred only
- acetaldehyde is metabolised by ALDH9A1ProteinHuman-GEM MAR08357Inferred only
- acetaldehyde is metabolised by ALDH9A1ProteinRhea RHEA:25294Inferred only
- acetaldehyde is a substrate of DERAProteinHuman-GEM MAR04398Inferred only
- acetaldehyde is a substrate of DERAProteinRhea RHEA:12821Inferred only
- acetaldehyde is a substrate of ETNPPLProteinRhea RHEA:17889Inferred only
Reactions
73 reactions
ethanolamineacetaldehyde+proton+ammonium
Reaction pageLeft to rightBalancedEC 4.3.1.7cytosol
Human-GEM MAR00647CC BY 4.0Reference data
acetaldehyde+water+NAD(+)acetate+2proton+NADH(2-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2 or ALDH1A3
Reaction pageLeft to rightBalancedEC 1.2.1.4, 1.2.1.5cytosol
Human-GEM MAR01568CC BY 4.0Reference data
17alpha-hydroxypregnenolone+2proton+2NADPH(4-)+dioxygenacetaldehyde+3beta-hydroxyandrost-5-en-17-one+2water+2NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 1.14.14.32cytosol
Human-GEM MAR01958CC BY 4.0Reference data
cortisol+proton+NADPH(4-)11beta-hydroxyandrost-4-ene-3,17-dione+acetaldehyde+water+NADP(3-)
Catalysed by CYP17A1
Reaction pageLeft to rightBalancedEC 2.3.1.65endoplasmic reticulum
Human-GEM MAR03257CC BY 4.0Reference data
ethanol+NAD(+)acetaldehyde+proton+NADH(2-)
Catalysed by ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.71cytosol
Human-GEM MAR03905CC BY 4.0Reference data
ethanol+NADP(3-)acetaldehyde+proton+NADPH(4-)
Catalysed by AKR1A1
Reaction pageLeft to rightBalancedEC 1.1.1.2cytosol
Human-GEM MAR03907CC BY 4.0Reference data
acetaldehyde+water+NADP(3-)acetate+2proton+NADPH(4-)
Catalysed by ALDH3B1 or ALDH3A1 or ALDH3B2
Reaction pageLeft to rightBalancedEC 1.2.1.5cytosol
Human-GEM MAR04283CC BY 4.0Reference data
CHEBI:16857acetaldehyde+glycine
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR04284CC BY 4.0Reference data
O-phosphoethanolamine+wateracetaldehyde+proton+ammonium+phosphate(3-)
Catalysed by ETNPPL
Reaction pageLeft to rightBalancedEC 4.2.3.2cytosol
Human-GEM MAR04296CC BY 4.0Reference data
CHEBI:16132acetaldehyde+CHEBI:29052
Catalysed by DERA
Reaction pageReversibleBalancedEC 4.1.2.4cytosol
Human-GEM MAR04398CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR04948CC BY 4.0Reference data
water+MAM02875cacetaldehyde+dopamine
Reaction pageReversibleBalancedcytosol
Human-GEM MAR06734CC BY 4.0Reference data
Other names
4 names
Resolves to: acetaldehyde
- Also called
- acetaldehydesacetic aldehydeEthanalethyl aldehyde