indole-3-pyruvate

Three steps

• acetylpyruvateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by AADAT, AGXT, AGXT2, FAHD1

• all-trans-retinoic acidReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by AADAT, AGXT, AGXT2, SLC16A4 and 5 moreextracellular space, cytosolOne of 2 routes

• propionyl-CoAReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
  3. 2-oxobutyrate oxidation

  Catalysed by AADAT, AGXT2cytosol

• CHEBI:15570Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5, SLC3A2, SLC7A10extracellular space, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by AADAT, SLC7A5, GNMTextracellular space, cytosol

• trimethylenediamineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of lysine and tryptophan (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by AADAT, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of histidine and tryptophan (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by AADAT, SLC7A6, CARNS1extracellular space, cytosol

• formateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan + O2 = N-formyl-L-kynurenine
  3. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

  Catalysed by AADAT, IDO1, TDO2, IDO2 and 1 moreOne of 3 routes

• CHEBI:15765Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of tryptophan and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by AADAT, SLC7A5, THextracellular space, cytosolOne of 5 routes

• 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. 3-hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

  Catalysed by AADAT, SLC7A5, KYAT1, KYAT3extracellular space, cytosol

• malonateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

  Catalysed by AADAT, CLYBL, SLC25A10inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-hydroxyanthranilic acidReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. 3-Hydroxy-L-kynurenine hydrolase

  Catalysed by AADAT, SLC7A5, KYNUextracellular space, cytosol

• N-carbamoyl-L-aspartic acidReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by AADAT, SLC7A13, CADinner side of the membrane, outer side of the membrane, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by AADAT, SLC7A5, GFPT2, GFPT1extracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by AADAT, WARS1cytosolOne of 2 routes

• homogentisateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by AADAT, HPDcytosolOne of 2 routes

• sulfateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by AADAT, SLC6A14, SLC26A6extracellular space, cytosolOne of 11 routes

• ureaReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-Arginine amidinohydrolase

  Catalysed by AADAT, SLC7A6, ARG1extracellular space, cytosolOne of 3 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AADAT, AGXT, AGXT2mitochondrial matrix

• L-cystineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by AADAT, SLC7A5, SLC7A9, SLC3A1extracellular space, cytosolOne of 9 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by AADAT, SLC7A5, AGXT2extracellular space, cytosol, mitochondrial matrix

• (R)-carnitineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

  Catalysed by AADAT, SLC22A6, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• iodideReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of tryptophan and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by AADAT, SLC7A5, TPOextracellular space, cytosolOne of 3 routes

• oxaloacetateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Aspartate:2-oxoglutarate aminotransferase

  Catalysed by AADAT, SLC7A13, GOT2inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 14 routes

• nitric oxideReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by AADAT, SLC7A6, NOS3, NOS1 and 1 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16523Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by AADAT, SLC7A5, SLC3A2, SLC7A10extracellular space, cytosolOne of 4 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by AADAT, SLC7A6, ACY1extracellular space, cytosol

• 2-phenylacetamideReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by AADAT, SLC7A5, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of alanine and tryptophan (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AADAT, SLC7A5, SCLYextracellular space, cytosol

• Met-tRNA(Met)Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of methionine and tryptophan (cytosol to extracellular)
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by AADAT, SLC7A5, MARS1extracellular space, cytosol

• (S)-lactateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)

  Catalysed by AADAT, AGXT, AGXT2, LDHA and 4 more

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by AADAT, SLC7A5, CNDP2extracellular space, cytosol

• 2-oxoglutaramateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glutamine and tryptophan (cytosol to extracellular)
  3. L-Glutamine:pyruvate aminotransferase

  Catalysed by AADAT, SLC7A5, KYAT1extracellular space, cytosolOne of 6 routes

• enol-phenylpyruvateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by AADAT, MIF

• 3-fumarylpyruvateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

  Catalysed by AADAT, AGXT, AGXT2, FAHD1

• CHEBI:16856Reach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by AADAT, SLC7A5, GSSextracellular space, cytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of glycine and tryptophan (cytosol to extracellular)
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by AADAT, SLC7A5, DAOextracellular space, cytosol, peroxisomeOne of 4 routes

• N-acetyl-L-aspartateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. acetyl-CoA:L-aspartate N-acetyltransferase

  Catalysed by AADAT, SLC7A13, NAT8Linner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• oxalic acidReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by AADAT, SLC6A14, SLC26A6extracellular space, cytosol

• (R)-3-hydroxybutyric acidReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

  Catalysed by AADAT, AGXT, AGXT2, SLC16A4 and 5 moreextracellular space, cytosolOne of 2 routes

• 3-hydroxypyruvateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

  Catalysed by AADAT, AGXT, AGXT2

• (S)-4-hydroxymandelateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2

  Catalysed by AADAT, HPDL

• L-glutamic 5-semialdehydeReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-Ornithine:2-oxo-acid aminotransferase

  Catalysed by AADAT, SLC7A6, OATextracellular space, cytosol, mitochondrial matrix

• itaconateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membrane

• aceneuramateReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

  Catalysed by AADAT, AGXT, AGXT2, NPL

• 5'-deoxyadenosineReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + L-alanine = glycine + pyruvate
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by AADAT, AGXT, AGXT2, TYW1B and 1 more

• 3-hydroxy-3-methylglutarateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by AADAT, SLC22A6, SUGCTinner side of the membrane, outer side of the membrane

• sulfiteReach from here →
  1. L-tryptophan + glyoxylate = indole-3-pyruvate + glycine
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by AADAT, CLYBL, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of proline and tryptophan (cytosol to extracellular)
  3. L-proline:(acceptor) oxidoreductase

  Catalysed by AADAT, ABCA1, SLC7A5, PRODH2extracellular space, cytosolOne of 2 routes

• agmatineReach from here →
  1. indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O
  2. transport of arginine and tryptophan (cytosol to extracellular)
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by AADAT, SLC7A6extracellular space, cytosol, mitochondrial matrix