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Proteins/UNIPROT:Q9UF12
Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis..
Function from UniProtKB (Q9UF12), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
21 statements
21 statements · 6 reference databases · Subject: PRODH2 · Sources: Bgee, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
5 names
Resolves to: PRODH2
Catalysed by PRODH2
Reaction pageLeft to rightBalancedEC 1.5.5.2cytosol
Human-GEM MAR08610CC BY 4.0Reference data
FAD+CHEBI:17203(S)-1-pyrroline-5-carboxylate+FADH2+proton
Reaction pageLeft to rightBalancedEC 1.5.5.2mitochondrial matrix
Human-GEM MAR08611CC BY 4.0Reference data
L-proline+a quinone(S)-1-pyrroline-5-carboxylate+a quinol+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:23784CC BY 4.0Reference data
trans-4-hydroxy-L-proline+a quinone(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+a quinol+hydron
Catalysed by PRODH2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:52512CC BY 4.0Reference data