Compound
L-glutamic 5-semialdehyde
A glutamic semialdehyde arising from formal reduction of the side-chain carboxy group of L-glutamic acid.
Definition from ChEBI (CHEBI:17232), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
11 statements
11 statements · 1 reference database · Subject: L-glutamic 5-semialdehyde · Sources: Human-GEM
- L-glutamic 5-semialdehyde is converted to (S)-1-pyrroline-5-carboxylateCompoundHuman-GEM MAR03820Inferred only
- L-glutamic 5-semialdehyde is converted to (S)-1-pyrroline-5-carboxylateCompoundHuman-GEM MAR03819Inferred only
- (S)-1-pyrroline-5-carboxylate is converted to L-glutamic 5-semialdehydeCompoundHuman-GEM MAR03819Inferred only
- (S)-1-pyrroline-5-carboxylate is converted to L-glutamic 5-semialdehydeCompoundHuman-GEM MAR03820Inferred only
- L-glutamyl 5-phosphate is converted to L-glutamic 5-semialdehydeCompoundHuman-GEM MAR03897Inferred only
- L-glutamic 5-semialdehyde is converted to L-ornithineCompoundHuman-GEM MAR03807Inferred only
- L-ornithine is converted to L-glutamic 5-semialdehydeCompoundHuman-GEM MAR03807Inferred only
- L-glutamic 5-semialdehyde is metabolised by ALDH4A1ProteinHuman-GEM MAR03819Inferred only
- L-glutamic 5-semialdehyde is metabolised by ALDH4A1ProteinHuman-GEM MAR03806Inferred only
- L-glutamic 5-semialdehyde is metabolised by ALDH4A1ProteinHuman-GEM MAR03820Inferred only
- L-glutamic 5-semialdehyde is a substrate of OATProteinHuman-GEM MAR03807Inferred only
Reactions
6 reactions
L-glutamate(1-)+2proton+NADH(2-)water+L-glutamic 5-semialdehyde+NAD(+)
Catalysed by ALDH4A1
Reaction pageReversibleBalancedEC 1.2.1.88GO:0005759
Human-GEM MAR03806CC BY 4.0Reference data
2-oxoglutarate(2-)+L-ornithineL-glutamate(1-)+L-glutamic 5-semialdehyde
Catalysed by OAT
Reaction pageReversibleBalancedEC 2.6.1.13GO:0005759
Human-GEM MAR03807CC BY 4.0Reference data
L-glutamic 5-semialdehydeL-glutamic 5-semialdehyde
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR03818CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+proton+waterL-glutamic 5-semialdehyde
Catalysed by ALDH4A1
Reaction pageReversibleBalancedEC 1.2.1.88GO:0005829
Human-GEM MAR03819CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+proton+waterL-glutamic 5-semialdehyde
Catalysed by ALDH4A1
Reaction pageReversibleBalancedEC 1.2.1.88GO:0005759
Human-GEM MAR03820CC BY 4.0Reference data
L-glutamyl 5-phosphate+proton+NADPH(4-)L-glutamic 5-semialdehyde+NADP(3-)+phosphate(3-)
Catalysed by ALDH18A1
Reaction pageLeft to rightBalancedEC 1.2.1.41GO:0005759
Human-GEM MAR03897CC BY 4.0Reference data
Other names
4 names
Resolves to: L-glutamic 5-semialdehyde
- Also called
- 5-oxo-L-norvalineL-Glutamate 5-semialdehydeL-Glutamate gamma-semialdehyde
- Systematic name
- (2S)-2-amino-5-oxopentanoic acid