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Proteins/UNIPROT:P23381
Catalyzes the attachment of tryptophan to tRNA(Trp) in a two-step reaction: tryptophan is first activated by ATP to form Trp-AMP and then transferred to the acceptor end of the tRNA(Trp)..
[Isoform 1]: Has no angiostatic activity..
[T2-TrpRS]: Possesses an angiostatic activity but has no aminoacylation activity. Inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression..
[Isoform 2]: Has an angiostatic activity..
Function from UniProtKB (P23381), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
167 statements
167 statements · 8 reference databases · Subject: WARS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
ATP+MAM03080c+L-tryptophanAMP+Trp-tRNA(Trp)+diphosphate(3-)
Catalysed by WARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.2cytosol
Human-GEM MAR05149CC BY 4.0Reference data
CHEBI:78442+L-tryptophan+ATP(4-)CHEBI:78535+AMP+diphosphate(3-)+
9 names
Resolves to: WARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:24080CC BY 4.0Reference data