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Proteins/UNIPROT:O95477
Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain..
Function from UniProtKB (O95477), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
3 rows
131 statements
131 statements · 6 reference databases · Subject: ABCA1 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
76 reactions
ATP+water+MAM03051cADP+proton+phosphate(3-)+MAM03051e
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00194CC BY 4.0Reference data
7 names
Resolves to: ABCA1
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00202CC BY 4.0Reference data
MAM00117c+ATP+waterMAM00117e+ADP+proton+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00207CC BY 4.0Reference data
ATP+water+MAM02745cADP+proton+MAM02745e+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00211CC BY 4.0Reference data
ATP+water+hexadecanoic acidADP+proton+hexadecanoic acid+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00224CC BY 4.0Reference data
MAM00003c+ATP+waterMAM00003e+ADP+proton+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00243CC BY 4.0Reference data
ATP+water+octadecanoateADP+proton+phosphate(3-)+octadecanoate
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00253CC BY 4.0Reference data
MAM00019c+ATP+waterMAM00019e+ADP+proton+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00257CC BY 4.0Reference data
ATP+MAM01585c+waterADP+MAM01585e+proton+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00261CC BY 4.0Reference data
ATP+water+(9Z)-octadecenoateADP+proton+(9Z)-octadecenoate+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00265CC BY 4.0Reference data
MAM00115c+ATP+waterMAM00115e+ADP+proton+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00273CC BY 4.0Reference data
ATP+water+MAM02613cADP+proton+MAM02613e+phosphate(3-)
Transported by ABCA1
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR00281CC BY 4.0Reference data