L-glutamic 5-semialdehyde

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

218 compounds within 3 steps: 2 in 1, 33 in 2, 183 in 3

One step

(S)-1-pyrroline-5-carboxylateReach from here →
1. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)
Catalysed by ALDH4A1cytosolOne of 2 routes
L-ornithineReach from here →
1. L-Ornithine:2-oxo-acid aminotransferase
Catalysed by OATmitochondrial matrix

Two steps

a quinoneReach from here →
1. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)
2. L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
Catalysed by ALDH4A1, PRODH, PRODH2cytosol
D-histidineReach from here →
1. L-Ornithine:2-oxo-acid aminotransferase
2. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)
Catalysed by OAT, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes
L-homoarginine

Three steps

beta-carbolineReach from here →
Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosol
CHEBI:1146900Reach from here →
Catalysed by OAT, ODC1

Reach from here →

Catalysed by OAT, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

L-leucineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

CHEBI:15699Reach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

CHEBI:15971Reach from here →

Catalysed by OAT, SLC7A5, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

L-citrullineReach from here →

Catalysed by OAT, SLC7A9mitochondrial matrix, extracellular space, cytosolOne of 9 routes

L-valineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-arginineReach from here →

Catalysed by OAT, GATMmitochondrial matrix, cytosolOne of 7 routes

N(2)-acetyl-L-ornithineReach from here →

Catalysed by OAT, ACY1mitochondrial matrix, cytosol

CHEBI:16857Reach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-isoleucineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

CHEBI:17203Reach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 6 routes

L-cysteineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

CHEBI:17895Reach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

CHEBI:18019Reach from here →

Catalysed by OAT, SLC7A5, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

L-glutamineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-lysineReach from here →

Catalysed by OAT, SLC25A2, SLC25A15mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

D-lysineReach from here →

Catalysed by OAT, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

putrescineReach from here →

Catalysed by OAT, ODC1mitochondrial matrix, cytosolOne of 3 routes

D-arginineReach from here →

Catalysed by OAT, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

glycineReach from here →

Catalysed by OAT, GATMmitochondrial matrix, cytosolOne of 4 routes

L-histidineReach from here →

Catalysed by OAT, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

D-ornithineReach from here →

Catalysed by OAT, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

L-methionineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-tryptophanReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-alanineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 3 routes

L-asparagineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

L-glutamate 5-semialdehydeReach from here →

Catalysed by OATmitochondrial matrix

L-phenylalanineReach from here →

Catalysed by OAT, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 2 routes

N(omega),N(omega)-dimethyl-L-arginineReach from here →

Catalysed by OAT, SLC25A2mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

5-amino-2-oxopentanoateReach from here →

Catalysed by OAT, AGXT2mitochondrial matrixOne of 2 routes

L-prolineReach from here →

Catalysed by ALDH4A1, PYCR1, PYCR3, PYCR2cytosolOne of 3 routes

, SAT1

, SAT2

mitochondrial matrix, cytosol

One of 40 routes

N(omega)-methyl-L-arginineReach from here →

Catalysed by OAT, GATM, SLC25A29mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

3-methyl-2-oxobutanoateReach from here →

Catalysed by OAT, SLC7A6, BCAT2mitochondrial matrix, extracellular space, cytosolOne of 3 routes

AReach from here →

Catalysed by OAT, SLC7A6, MOCOSmitochondrial matrix, extracellular space, cytosol

glycoursodeoxycholateReach from here →

Catalysed by OAT, GATMmitochondrial matrix, cytosolOne of 2 routes

epsilon-(gamma-L-glutamyl)-L-lysineReach from here →

Catalysed by OAT, SLC25A2, SLC25A15, GGACTmitochondrial matrix, inner side of the membrane, outer side of the membrane

N-(9Z-octadecenoyl)glycineReach from here →

Catalysed by OAT, GATM, GLYATL3, GLYATL2mitochondrial matrix, cytosol

N-(9Z-octadecenoyl)-L-phenylalanineReach from here →

Catalysed by OAT, SLC7A6, PM20D1mitochondrial matrix, extracellular space, cytosol

N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →

Catalysed by OAT, SLC7A6, PM20D1mitochondrial matrix, extracellular space, cytosol

N-(9Z-octadecenoyl)-L-leucineReach from here →

Catalysed by OAT, SLC7A6, PM20D1mitochondrial matrix, extracellular space, cytosol

N-octadecanoylglycineReach from here →

Catalysed by OAT, GATM, GLYATL2mitochondrial matrix, cytosol

N-(9Z-hexadecenoyl)-glycineReach from here →

Catalysed by OAT, GATM, GLYATL2mitochondrial matrix, cytosol

a 1,4-benzosemiquinoneReach from here →

Catalysed by ALDH4A1, PRODH, PRODH2, CRYZ and 3 morecytosol

N-hexadecanoylglycineReach from here →

Catalysed by OAT, GATM, GLYATL3mitochondrial matrix, cytosol