Loading the page.
Proteins/UNIPROT:Q6ZQW0
Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance..
Function from UniProtKB (Q6ZQW0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
15 statements
15 statements · 6 reference databases · Subject: IDO2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
5 reactions
dioxygen+L-tryptophanCHEBI:30249
Catalysed by IDO1 or TDO2 or IDO2
Reaction pageLeft to rightBalancedEC 1.13.11.11, 1.13.11.52cytosol
Human-GEM MAR04214CC BY 4.0Reference data
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol
4 names
Resolves to: IDO2
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol
Human-GEM MAR04557CC BY 4.0Reference data
5-hydroxytryptophan+dioxygenMAM01108c
Reaction pageLeft to rightBalancedEC 1.13.11.52cytosol
Human-GEM MAR06716CC BY 4.0Reference data
L-tryptophan+dioxygenN-formyl-L-kynurenine
Catalysed by IDO1 or TDO2 or IDO2
Reaction pageDirection not assertedBalanced
Rhea RHEA:24536CC BY 4.0Reference data