Compound
3-hydroxy-3-methylglutarate
A dicarboxylic acid dianion that results from the removal of a proton from both of the carboxylic acid groups of 3-hydroxy-3-methylglutaric acid.
Definition from ChEBI (CHEBI:17325), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C6H8O5
- Mass
- 160.125 g/mol
- Charge
- -2
- InChIKey
- NPOAOTPXWNWTSH-UHFFFAOYSA-L
- SMILES
- CC(O)(CC(=O)[O-])CC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What the reference databases state
Chemical structure
- 3-hydroxy-3-methylglutarate has the functional parent glutarateCompoundChEBI CHEBI:17325Inferred only
Statements
3 statements
3 statements · 1 reference database · Subject: 3-hydroxy-3-methylglutarate · Sources: Rhea
- (3S)-3-hydroxy-3-methylglutaryl-CoA is converted to 3-hydroxy-3-methylglutarateCompoundRhea RHEA:16305Inferred only
- 3-hydroxy-3-methylglutarate is a substrate of SUGCTProteinRhea RHEA:12284Inferred only
- 3-hydroxy-3-methylglutarate is a substrate of SUGCTProteinRhea RHEA:81723Inferred only
Reactions
7 reactions
water+CHEBI:15467CHEBI:1146900+proton+3-hydroxy-3-methylglutarate
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR11492CC BY 4.0Reference data
3-hydroxy-3-methylglutarate3-hydroxy-3-methylglutarate
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR11493CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR11494CC BY 4.0Reference data
3-hydroxy-3-methylglutarate+succinyl-CoA(3S)-3-hydroxy-3-methylglutaryl-CoA+succinate(2-)
Catalysed by SUGCT
Reaction pageReversibleBalanced
Rhea RHEA:12284CC BY 4.0Reference data
(3S)-3-hydroxy-3-methylglutaryl-CoA+water3-hydroxy-3-methylglutarate+coenzyme A(4-)+hydron
Catalysed by ACOT8
Reaction pageLeft to rightBalanced
Rhea RHEA:16305CC BY 4.0Reference data
3-hydroxy-3-methylglutarate+malonyl-CoA(3S)-3-hydroxy-3-methylglutaryl-CoA+malonate
Reaction pageDirection not assertedBalanced
Rhea RHEA:24948CC BY 4.0Reference data
3-hydroxy-3-methylglutarate+glutaryl-CoA(3S)-3-hydroxy-3-methylglutaryl-CoA+glutarate
Catalysed by SUGCT
Reaction pageReversibleBalanced
Rhea RHEA:81723CC BY 4.0Reference data
Other names
1 name
Resolves to: 3-hydroxy-3-methylglutarate
- Systematic name
- 3-hydroxy-3-methylpentanedioate