3-hydroxy-3-methylglutarate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

80 compounds within 3 steps: 2 in 1, 17 in 2, 61 in 3

One step

glutarateReach from here →
1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
Catalysed by SUGCT
(3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
Catalysed by SUGCTOne of 2 routes

Two steps

acetoacetateReach from here →
1. 3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate
2. (3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA
Catalysed by SUGCT, HMGCL, HMGCLL1
(R)-carnitineReach from here →
1. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate
2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
Catalysed by SUGCT, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes
itaconate

Three steps

Reach from here →

Catalysed by SUGCT

urateReach from here →

Catalysed by SUGCT, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →

Catalysed by SUGCT, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

glycocholateReach from here →

Catalysed by SUGCT, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

adipic acidReach from here →

Catalysed by SUGCT

taurocholateReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

(R)-mevalonateReach from here →

Catalysed by SUGCT, HMGCR

succinyl-CoAReach from here →

Catalysed by SUGCT

glutaryl-CoAReach from here →

Catalysed by SUGCTOne of 5 routes

prostaglandin F2alphaReach from here →

Catalysed by SUGCT, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

dehydroepiandrosterone 3-sulfateReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

kynurenateReach from here →

Catalysed by SUGCT, SLC22A6inner side of the membrane, outer side of the membraneOne of 2 routes

estrone 3-sulfateReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8, SLC22A11inner side of the membrane, outer side of the membraneOne of 2 routes

prostaglandin E2Reach from here →

Catalysed by SUGCT, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

17beta-estradiol 17-O-(beta-D-glucuronate)Reach from here →

Catalysed by SUGCT, SLC22A24inner side of the membrane, outer side of the membraneOne of 2 routes

Catalysed by SUGCT, CPT1A, CPT1C, CPT1B

cytosol

2-hydroxybutyric acidReach from here →

Catalysed by SUGCT, HMGCL, HMGCLL1, SLC16A4 and 3 moreextracellular space, cytosolOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by SUGCT, SLC22A8, SCARF2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

15-oxoprostaglandin F2alphaReach from here →

Catalysed by SUGCT, SLC22A8inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 12 routes

CHEBI:15345Reach from here →

Catalysed by SUGCT, HMGCL, HMGCLL1, AACScytosolOne of 3 routes

acetoneReach from here →

Catalysed by SUGCT, HMGCL, HMGCLL1mitochondrial matrix

pyruvateReach from here →

Catalysed by SUGCT, HMGCL, HMGCLL1mitochondrial matrix, cytosolOne of 4 routes

all-trans-retinoic acidReach from here →

Catalysed by SUGCT, HMGCL, HMGCLL1, SLC16A4 and 1 moreextracellular space, cytosolOne of 2 routes

sulfateReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 6 routes

ureaReach from here →

Catalysed by SUGCT, SLC22A8, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

(S)-lactateReach from here →

Catalysed by SUGCT, SLC22A8, SLCO2A1inner side of the membrane, outer side of the membraneOne of 5 routes

CHEBI:16856Reach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8, SLCO1A2 and 1 moreinner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes

(R)-3-hydroxybutyric acidReach from here →

Catalysed by SUGCT, HMGCL, HMGCLL1, BDH1 and 1 moremitochondrial matrixOne of 4 routes

CHEBI:17208Reach from here →

Catalysed by SUGCT, SLC22A8inner side of the membrane, outer side of the membrane, cytosol

succinyl-4'-phosphopantetheineReach from here →

Catalysed by SUGCT, NUDT19, NUDT7, NUDT8

estroneReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

propanoateReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

O-hexadecanoyl-(R)-carnitineReach from here →

Catalysed by SUGCT, SLC22A8, CPT2, CPT1A and 1 moreinner side of the membrane, outer side of the membraneOne of 3 routes

xanthineReach from here →

Catalysed by SUGCT, SLC22A8, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

glycine betaineReach from here →

Catalysed by SUGCT, SLC22A8, SLC22A5inner side of the membrane, outer side of the membraneOne of 2 routes

17beta-estradiol 17-O-(3-sulfo-beta-D-glucuronate)Reach from here →

Catalysed by SUGCT, SLC22A24, CHST10inner side of the membrane, outer side of the membrane

butanoateReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8, SLC22A11 and 1 moreinner side of the membrane, outer side of the membraneOne of 4 routes

4-fumarylacetoacetateReach from here →

Catalysed by SUGCT, HMGCL, HMGCLL1, FAH

5-hydroxyisourateReach from here →

Catalysed by SUGCT, SLC22A8inner side of the membrane, outer side of the membrane, cytosol

O-octanoyl-(R)-carnitineReach from here →

Catalysed by SUGCT, SLC22A8, CPT2, CRAT and 1 moreinner side of the membrane, outer side of the membraneOne of 3 routes

O-butanoyl-(R)-carnitineReach from here →

Catalysed by SUGCT, SLC22A8, CRATinner side of the membrane, outer side of the membrane

3beta-hydroxyandrost-5-en-17-oneReach from here →

Catalysed by SUGCT, SLC22A24, SLC22A8, STSinner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

O-decanoyl-(R)-carnitineReach from here →

Catalysed by SUGCT, SLC22A8, CPT2, CRATinner side of the membrane, outer side of the membrane

a dicarboxylateReach from here →

Catalysed by SUGCT, SLC22A8, SLC22A6inner side of the membrane, outer side of the membraneOne of 8 routes