5-amino-2-oxopentanoate

Three steps

• sulfateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. transport of malate and sulfate (cytosol to mitochondria)

  Catalysed by AGXT2, ME2, SLC25A10mitochondrial matrix, cytosolOne of 6 routes

• ureaReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. L-Arginine amidinohydrolase

  Catalysed by AGXT2, GATM, ARG1cytosolOne of 3 routes

• L-cystineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by AGXT2, SLC7A9, SLC3A1mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• CHEBI:16284Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. pyruvate kinase (dTDP)
  3. deoxythymidylate kinase (dADP)

  Catalysed by AGXT2, PKM, PKLR, DTYMKcytosol, mitochondrial matrixOne of 3 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by AGXT2, ABATmitochondrial matrixOne of 3 routes

• iodideReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by AGXT2, SLC7A6, TPOextracellular space, cytosolOne of 2 routes

• nitric oxideReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)

  Catalysed by AGXT2, GATM, NOS3, NOS1 and 1 morecytosolOne of 2 routes

• CHEBI:16497Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by AGXT2, PKM, PKLRcytosol

• CHEBI:16523Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. transport of D-serine and glycine (cytosol to extracellular)

  Catalysed by AGXT2, GATM, SLC3A2, SLC7A10cytosol, extracellular spaceOne of 4 routes

• protein polypeptide chainReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. PROTEIN_BS

  Catalysed by AGXT2mitochondrial matrix, cytosolOne of 17 routes

• 2-phenylacetamideReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine:oxygen 2-oxidoreductase (decarboxylating)

  Catalysed by AGXT2, SLC7A6, EPXextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by AGXT2, SCLYmitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by AGXT2, TYW1B, TYW1, MARS1cytosol

• (R)-glycerateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by AGXT2, AGXT, GRHPRcytosolOne of 4 routes

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by AGXT2, LDHA, LDHB, LDHC and 3 moreOne of 2 routes

• tryptamineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan decarboxy-lyase

  Catalysed by AGXT2, SLC7A6, DDCextracellular space, cytosol

• enol-phenylpyruvateReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. glyoxylate + L-phenylalanine = 3-phenylpyruvate + glycine
  3. 3-phenylpyruvate = enol-phenylpyruvate

  Catalysed by AGXT2, AADAT, MIF

• CHEBI:16856Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)

  Catalysed by AGXT2, GATM, GSScytosolOne of 2 routes

• glyoxylic acidReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. glycine:oxygen oxidoreductase (deaminating)

  Catalysed by AGXT2, GATM, DAOcytosol, peroxisomeOne of 4 routes

• ferrocytochrome cReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by AGXT2, LDHB, LDHAL6B, CYB5D1mitochondrial matrix, cytosolOne of 2 routes

• glycolaldehydeReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by AGXT2, AGXTcytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by AGXT2, NPLcytosolOne of 2 routes

• (S)-4-hydroxymandelateReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2

  Catalysed by AGXT2, AADAT, HPDL

• 17alpha-hydroxyprogesteroneReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol, endoplasmic reticulum

• sulfiteReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by AGXT2, ME2, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• CHEBI:17380Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. Transport of 3-Hydroxy-L-Kynurenine

  Catalysed by AGXT2, SLC7A6, SLC7A5extracellular space, cytosolOne of 4 routes

• (S)-1-pyrroline-5-carboxylateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Ornithine:2-oxo-acid aminotransferase
  3. aldehyde dehydrogenase (1-pyrroline-5-carboxylate)

  Catalysed by AGXT2, OAT, ALDH4A1mitochondrial matrix, cytosolOne of 4 routes

• agmatineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. L-arginine carboxy-lyase (agmatine-forming)

  Catalysed by AGXT2, GATMcytosol, mitochondrial matrix

• enol-oxaloacetateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by AGXT2, ME2, SDHB, SDHA

• AH2Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by AGXT2, MOCOSmitochondrial matrixOne of 7 routes

• S-methyl-5'-thioadenosineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. S-adenosylmethioninamine:putrescine 3-aminopropyltransferase

  Catalysed by AGXT2, ODC1, SRMcytosolOne of 2 routes

• 5-aminolevulinic acidReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. succinyl-CoA:glycine C-succinyltransferase (decarboxylating)

  Catalysed by AGXT2, GATM, ALAS1, ALAS2 and 1 morecytosol, mitochondrial matrix

• Ala-tRNA(Ala)Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by AGXT2, AARS1mitochondrial matrix, cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 5 moreextracellular space, cytosol

• CHEBI:17769Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-ornithine carboxy-lyase (putrescine-forming)
  3. Putrescine:oxygen oxidoreductase (deaminating)

  Catalysed by AGXT2, ODC1, AOC2, AOC1 and 1 morecytosol, extracellular spaceOne of 2 routes

• trans-urocanateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine ammonia-lyase (urocanate-forming)

  Catalysed by AGXT2, SLC7A5, SLC7A6, HALextracellular space, cytosolOne of 2 routes

• urateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by AGXT2, LDHB, LDHAL6B, SLC22A12mitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by AGXT2, SLC7A6, TPH1, TPH2extracellular space, cytosol

• all-trans-retinalReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• CHEBI:17927Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. Transport by Y+Lat-2 into Extracellular Space

  Catalysed by AGXT2, GATM, SLC3A2, SLC7A6cytosol, extracellular space

• fumaric acidReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate hydro-lyase (fumarate-forming)

  Catalysed by AGXT2, ME2, FHcytosolOne of 6 routes

• thiocyanateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)

  Catalysed by AGXT2, MPST, TSTcytosol

• 4-fumarylacetoacetateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by AGXT2, FAHmitochondrial matrix, cytosol

• dTTPReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by AGXT2, PKM, PKLR, ENTPD3 and 2 morecytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by AGXT2, SLC1A4mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by AGXT2, GATM, GARTcytosol

• 2-phenylethylamineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by AGXT2, SLC7A6, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by AGXT2, SLC7A6, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by AGXT2, GATM, GSScytosol

• S-methylmercury-L-cysteineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by AGXT2, TYW1B, TYW1, SLC7A8inner side of the membrane, outer side of the membraneOne of 6 routes