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Proteins/UNIPROT:P49588
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1. Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins. Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53. Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1..
Function from UniProtKB (P49588), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
5 rows
460 statements
460 statements · 8 reference databases · Subject: AARS1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt · Rows fetched: 300
4 reactions
L-alanine+ATP+MAM03063cAMP+Ala-tRNA(Ala)+diphosphate(3-)
Catalysed by AARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.7cytosol
Human-GEM MAR05131CC BY 4.0Reference data
CHEBI:78442+L-alanine+ATP(4-)CHEBI:78497+AMP+diphosphate(3-)
Catalysed by
6 names
Resolves to: AARS1
Reaction pageDirection not assertedBalanced
Rhea RHEA:12540CC BY 4.0Reference data
(S)-lactate+ATP(4-)+hydron(S)-lactoyl-AMP+diphosphate(3-)
Reaction pageLeft to rightBalanced
Rhea RHEA:80271CC BY 4.0Reference data
(S)-lactoyl-AMP+L-lysyl-[protein]N(6)-[(S)-lactoyl]-L-lysyl-[protein]+AMP+2hydron
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:80275CC BY 4.0Reference data