5-hydroxy-L-tryptophan

1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

Catalysed by DDC

1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

Catalysed by TPH1, TPH2

1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

Catalysed by TPH1, TPH2

1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
2. beta-carboline hydrolysis

Catalysed by TPH1, TPH2cytosol

1. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2
2. acetyl-CoA:aralkylamine N-acetyltransferase

Catalysed by DDC, AANATcytosol

1. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
2. Transport of L-Tryptophan by Atb0 Transporter
3. Carnitine Transport by Atb0

Catalysed by TPH1, TPH2, SLC6A14extracellular space, cytosolOne of 245 routes