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Proteins/UNIPROT:P30038
Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes..
Function from UniProtKB (P30038), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
82 statements
82 statements · 7 reference databases · Subject: ALDH4A1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
12 reactions
MAM01685m+2water+NAD(+)MAM01681m+3proton+NADH(2-)
Catalysed by ALDH2 or ALDH1B1 or ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR01372CC BY 4.0Reference data
5 names
Resolves to: ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.3mitochondrial matrix
Human-GEM MAR01474CC BY 4.0Reference data
water+4-acetamidobutanal+NAD(+)MAM00952m+2proton+NADH(2-)
Catalysed by ALDH2 or ALDH1B1 or ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR01523CC BY 4.0Reference data
L-glutamate(1-)+2proton+NADH(2-)water+L-glutamic 5-semialdehyde+NAD(+)
Catalysed by ALDH4A1
Reaction pageReversibleBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR03806CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+proton+waterL-glutamic 5-semialdehyde
Catalysed by ALDH4A1
Reaction pageReversibleBalancedEC 1.2.1.88cytosol
Human-GEM MAR03819CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+proton+waterL-glutamic 5-semialdehyde
Catalysed by ALDH4A1
Reaction pageReversibleBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR03820CC BY 4.0Reference data
(S)-1-pyrroline-5-carboxylate+2water+NAD(+)L-glutamate(1-)+proton+NADH(2-)
Catalysed by ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR03822CC BY 4.0Reference data
2water+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NAD(+)proton+MAM02358m+NADH(2-)
Catalysed by ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR04784CC BY 4.0Reference data
2water+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate+NADP(3-)proton+MAM02358m+NADPH(4-)
Catalysed by ALDH4A1
Reaction pageLeft to rightBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR04785CC BY 4.0Reference data
proton+water+(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylateMAM02327m
Catalysed by ALDH4A1
Reaction pageReversibleBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR08096CC BY 4.0Reference data
2proton+MAM02358m+NADH(2-)water+MAM02327m+NAD(+)
Catalysed by ALDH4A1
Reaction pageReversibleBalancedEC 1.2.1.88mitochondrial matrix
Human-GEM MAR08097CC BY 4.0Reference data
L-glutamate 5-semialdehyde+NAD(1-)+waterL-glutamate(1-)+NADH(2-)+2hydron
Catalysed by ALDH4A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:30235CC BY 4.0Reference data