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Proteins/UNIPROT:P11926
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis..
Function from UniProtKB (P11926), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
136 statements
136 statements · 8 reference databases · Subject: ODC1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
proton+L-ornithinecarbon dioxide+putrescine
Catalysed by ODC1
Reaction pageLeft to rightBalancedEC 4.1.1.17cytosol
Human-GEM MAR04212CC BY 4.0Reference data
proton+L-ornithinecarbon dioxide+putrescine
Catalysed by ODC1
Reaction pageLeft to rightBalancedEC 4.1.1.17extracellular space
1 name
Resolves to: ODC1
L-ornithine+hydronputrescine+carbon dioxide
Catalysed by ODC1
Reaction pageDirection not assertedBalanced
Rhea RHEA:22964CC BY 4.0Reference data