Compound
4-fumarylacetoacetate
A dicarboxylic acid dianion resuting from removal of a proton from both carboxy groups of 4-fumarylacetoacetic acid.
Definition from ChEBI (CHEBI:18034), read 2026-09-23. CC BY 4.0.
Structure
Loading the model…
- Class
- Organic compound, anion
- Formula
- C8H6O6
- Mass
- 198.13 g/mol
- Charge
- -2
- InChIKey
- GACSIVHAIFQKTC-OWOJBTEDSA-L
- SMILES
- O=C([O-])/C=C/C(=O)CC(=O)CC(=O)[O-]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
2 entities
2 entities reached.
0 reported hops2 assembled from the scaffold
What the reference databases state
Statements
6 statements
6 statements · 2 reference databases · Subject: 4-fumarylacetoacetate · Sources: Human-GEM, Rhea
- 4-fumarylacetoacetate is converted to 4-maleylacetoacetateCompoundRhea RHEA:14817Inferred only
- 4-maleylacetoacetate is converted to 4-fumarylacetoacetateCompoundRhea RHEA:14817Inferred only
- 4-maleylacetoacetic acid is converted to 4-fumarylacetoacetateCompoundHuman-GEM MAR06776Inferred only
- 4-fumarylacetoacetate is metabolised by GSTZ1ProteinRhea RHEA:14817Inferred only
- 4-fumarylacetoacetate is a substrate of FAHProteinHuman-GEM MAR06778Inferred only
- 4-fumarylacetoacetate is a substrate of FAHProteinRhea RHEA:10244Inferred only
Reactions
5 reactions
4-maleylacetoacetic acid4-fumarylacetoacetate
Catalysed by GSTZ1
Reaction pageLeft to rightBalancedEC 5.2.1.2cytosol
Human-GEM MAR06776CC BY 4.0Reference data
4-fumarylacetoacetate+wateracetoacetate+fumaric acid+proton
Catalysed by FAH
Reaction pageLeft to rightBalancedEC 3.7.1.2cytosol
Human-GEM MAR06778CC BY 4.0Reference data
4-fumarylacetoacetate+proton+NADH(2-)NAD(+)+MAM03956c
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR11462CC BY 4.0Reference data
4-fumarylacetoacetate+wateracetoacetate+fumaric acid+hydron
Catalysed by FAH
Reaction pageDirection not assertedBalanced
Rhea RHEA:10244CC BY 4.0Reference data
4-maleylacetoacetate4-fumarylacetoacetate
Catalysed by GSTZ1
Reaction pageDirection not assertedBalanced
Rhea RHEA:14817CC BY 4.0Reference data
Other names
3 names
Resolves to: 4-fumarylacetoacetate
- Also called
- 4-fumarylacetoacetate dianionfumarylacetoacetate
- Systematic name
- (2E)-4,6-dioxooct-2-enedioate