Loading the page.
Proteins/UNIPROT:O75355
Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates. This activity contributes to the regulation of extracellular levels of nucleotides. Has a preference for the hydrolysis of ATP. Does not hydrolyzes AMP..
Function from UniProtKB (O75355), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
26 statements
26 statements · 6 reference databases · Subject: ENTPD3 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
32 reactions
dTDP+waterdTMP+proton+phosphate(3-)
Catalysed by ENTPD1 or ENTPD3 or ENTPD8
Reaction pageReversibleBalancedEC 3.6.1.5extracellular space
Human-GEM MAR02124CC BY 4.0Reference data
dTTP+waterdTDP+proton+phosphate(3-)
Catalysed by
9 names
Resolves to: ENTPD3
Reaction pageReversibleBalancedEC 3.6.1.39extracellular space
Human-GEM MAR02125CC BY 4.0Reference data
ADP+waterAMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6cytosol
Human-GEM MAR03998CC BY 4.0Reference data
ADP+waterAMP+proton+phosphate(3-)
Catalysed by ENTPD1 or ENTPD3 or ENTPD8
Reaction pageLeft to rightBalancedEC 3.6.1.5extracellular space
Human-GEM MAR03999CC BY 4.0Reference data
water+UDPproton+phosphate(3-)+UMP
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6endoplasmic reticulum
Human-GEM MAR04059CC BY 4.0Reference data
water+UDPproton+phosphate(3-)+UMP
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6extracellular space
Human-GEM MAR04060CC BY 4.0Reference data
water+UTPproton+phosphate(3-)+UDP
Catalysed by ENTPD1 or ENTPD3 or ENTPD8
Reaction pageLeft to rightBalancedEC 3.6.1.39, 3.6.1.5extracellular space
Human-GEM MAR04061CC BY 4.0Reference data
GDP+waterGMP+proton+phosphate(3-)
Catalysed by ENTPD2 or ENTPD1 or ENTPD3 or CANT1 or ENTPD5 or ENTPD8 or ENTPD4 or ENTPD6
Reaction pageLeft to rightBalancedEC 3.6.1.5, 3.6.1.6, 3.6.1.42extracellular space
Human-GEM MAR04134CC BY 4.0Reference data
GTP+waterGDP+proton+phosphate(3-)
Catalysed by ENTPD2 or DNM2 or DNM1L or DNM1 or ENTPD1 or EFL1 or EEF1A1 or GFM2 or EEF2 or ENTPD3 or GFM1 or CANT1 and 5 more alternatives
Reaction pageLeft to rightBalancedEC 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6extracellular space
Human-GEM MAR04136CC BY 4.0Reference data
CHEBI:17239+watercytidine 5'-monophosphate+proton+phosphate(3-)
Catalysed by ENTPD1 or ENTPD3 or ENTPD8
Reaction pageLeft to rightBalancedEC 3.6.1.5extracellular space
Human-GEM MAR04183CC BY 4.0Reference data
CHEBI:17677+waterCHEBI:17239+proton+phosphate(3-)
Catalysed by ENTPD1 or ENTPD3 or ENTPD8
Reaction pageLeft to rightBalancedEC 3.6.1.5extracellular space
Human-GEM MAR04192CC BY 4.0Reference data
water+CHEBI:16039proton+CHEBI:17808+phosphate(3-)
Catalysed by ENTPD1 or ENTPD3 or ENTPD8
Reaction pageLeft to rightBalancedEC 3.6.1.5extracellular space
Human-GEM MAR04290CC BY 4.0Reference data