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Proteins/UNIPROT:P50440
Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain (Probable)..
Function from UniProtKB (P50440), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 4 · substrate of
4 compounds
4 compounds.
0 reported routes4 assembled routes
3 rows
108 statements
108 statements · 8 reference databases · Subject: GATM · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
5 reactions
L-arginine+glycineguanidinoacetate+L-ornithine
Catalysed by GATM
Reaction pageReversibleBalancedEC 2.1.4.1cytosol
Human-GEM MAR04582CC BY 4.0Reference data
L-arginine+glycineguanidinoacetate+L-ornithine
Catalysed by GATM
Reaction pageLeft to rightBalanced
Rhea RHEA:13201CC BY 4.0Reference data
3 names
Resolves to: GATM
4-aminobutanoate+L-arginine4-guanidinobutanoate+L-ornithine
Catalysed by GATM
Reaction pageLeft to rightBalanced
Rhea RHEA:75939CC BY 4.0Reference data
beta-alanine+L-arginine3-guanidinopropanoate+L-ornithine
Catalysed by GATM
Reaction pageLeft to rightBalanced
Rhea RHEA:75943CC BY 4.0Reference data
taurine+L-argininetaurocyamine+L-ornithine
Catalysed by GATM
Reaction pageLeft to rightBalanced
Rhea RHEA:75947CC BY 4.0Reference data