Compound
dTTP
A thymidine phosphate having a triphosphate group at the 5'-position.
Definition from ChEBI (CHEBI:18077), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
39 entities
39 entities reached.
0 reported hops39 assembled from the scaffold
- NME1ProteinUNIPROT:P15531substrate ofInferred only164 paths28 endpoints
- NME2ProteinUNIPROT:P22392substrate ofInferred only150 paths25 endpoints
- RFC5ProteinUNIPROT:P40937substrate ofInferred only87 paths87 endpoints
- POLD2ProteinUNIPROT:P49005substrate ofInferred only73 paths73 endpoints
- POLD1ProteinUNIPROT:P28340substrate ofInferred only69 paths69 endpoints
- PKMProteinUNIPROT:P14618substrate ofInferred only66 paths65 endpoints
- NME7ProteinUNIPROT:Q9Y5B8substrate ofInferred only60 paths12 endpoints
- POLD3ProteinUNIPROT:Q15054substrate ofInferred only60 paths60 endpoints
- POLEProteinUNIPROT:Q07864substrate ofInferred only52 paths52 endpoints
- POLA1ProteinUNIPROT:P09884substrate ofInferred only49 paths49 endpoints
- POLD4ProteinUNIPROT:Q9HCU8substrate ofInferred only49 paths49 endpoints
- POLE2ProteinUNIPROT:P56282substrate ofInferred only45 paths45 endpoints
Show the remaining 27
- POLA2ProteinUNIPROT:Q14181substrate ofInferred only44 paths44 endpoints
- NME3ProteinUNIPROT:Q13232substrate ofInferred only40 paths8 endpoints
- POLE4ProteinUNIPROT:Q9NR33substrate ofInferred only39 paths39 endpoints
- POLE3ProteinUNIPROT:Q9NRF9substrate ofInferred only38 paths38 endpoints
- NME4ProteinUNIPROT:O00746substrate ofInferred only37 paths9 endpoints
- POLBProteinUNIPROT:P06746substrate ofInferred only31 paths31 endpoints
- POLKProteinUNIPROT:Q9UBT6substrate ofInferred only31 paths31 endpoints
- NME6ProteinUNIPROT:O75414substrate ofInferred only30 paths6 endpoints
- POLHProteinUNIPROT:Q9Y253substrate ofInferred only27 paths27 endpoints
- REV3LProteinUNIPROT:O60673substrate ofInferred only20 paths20 endpoints
- POLIProteinUNIPROT:Q9UNA4substrate ofInferred only16 paths16 endpoints
- ENTPD1ProteinUNIPROT:P49961substrate ofInferred only13 paths13 endpoints
- AK1ProteinUNIPROT:P00568substrate ofInferred only12 paths12 endpoints
- PKLRProteinUNIPROT:P30613substrate ofInferred only11 paths11 endpoints
- SAMHD1ProteinUNIPROT:Q9Y3Z3substrate ofInferred only9 paths9 endpoints
- POLGProteinUNIPROT:P54098substrate ofInferred only9 paths9 endpoints
- AK4ProteinUNIPROT:P27144substrate ofInferred only8 paths8 endpoints
- POLLProteinUNIPROT:Q9UGP5substrate ofInferred only8 paths8 endpoints
- TENT4AProteinUNIPROT:Q5XG87substrate ofInferred only7 paths7 endpoints
- AK9ProteinUNIPROT:Q5TCS8substrate ofInferred only6 paths3 endpoints
- POLG2ProteinUNIPROT:Q9UHN1substrate ofInferred only6 paths6 endpoints
- POLMProteinUNIPROT:Q9NP87substrate ofInferred only5 paths5 endpoints
- ENTPD3ProteinUNIPROT:O75355substrate ofInferred only5 paths5 endpoints
- ENTPD8ProteinUNIPROT:Q5MY95substrate ofInferred only4 paths4 endpoints
- POLNProteinUNIPROT:Q7Z5Q5substrate ofInferred only4 paths4 endpoints
- POLQProteinUNIPROT:O75417substrate ofInferred only4 paths4 endpoints
- ASMTLProteinUNIPROT:O95671substrate ofInferred only1 path1 endpoint
What the reference databases state
Statements
85 statements
85 statements · 2 reference databases · Subject: dTTP · Sources: Human-GEM, Rhea
- dTDP is converted to dTTPCompoundRhea RHEA:79867Inferred only
- dTDP is converted to dTTPCompoundHuman-GEM MAR07887Inferred only
- dTDP is converted to dTTPCompoundRhea RHEA:19013Inferred only
- dTDP is converted to dTTPCompoundRhea RHEA:27682Inferred only
- dTTP is converted to dTDPCompoundRhea RHEA:19013Inferred only
- dTTP is converted to dTDPCompoundHuman-GEM MAR07886Inferred only
- dTTP is converted to dTDPCompoundHuman-GEM MAR04635Inferred only
- dTTP is converted to dTDPCompoundHuman-GEM MAR02125Inferred only
- dTTP is converted to dTDPCompoundRhea RHEA:79867Inferred only
- dTTP is converted to dTDPCompoundHuman-GEM MAR07887Inferred only
- dTDP is converted to dTTPCompoundHuman-GEM MAR02125Inferred only
- dTDP is converted to dTTPCompoundHuman-GEM MAR04635Inferred only
Show the remaining 73
- dTDP is converted to dTTPCompoundHuman-GEM MAR07886Inferred only
- dTTP is converted to dTMPCompoundRhea RHEA:28534Inferred only
- dTTP is converted to dTMPCompoundRhea RHEA:64956Inferred only
- dTMP is converted to dTTPCompoundRhea RHEA:64956Inferred only
- dTMP is converted to dTTPCompoundRhea RHEA:28534Inferred only
- dTTP is a substrate of AK1ProteinRhea RHEA:79867Inferred only
- dTTP is a substrate of AK4ProteinRhea RHEA:79867Inferred only
- dTTP is a substrate of AK9ProteinHuman-GEM MAR07886Inferred only
- dTTP is a substrate of AK9ProteinRhea RHEA:79867Inferred only
- dTTP is a substrate of ASMTLProteinRhea RHEA:28534Inferred only
- dTTP is a substrate of ENTPD1ProteinHuman-GEM MAR02125Inferred only
- dTTP is a substrate of ENTPD3ProteinHuman-GEM MAR02125Inferred only
- dTTP is a substrate of ENTPD8ProteinHuman-GEM MAR02125Inferred only
- dTTP is a substrate of NME1ProteinHuman-GEM MAR06614Inferred only
- dTTP is a substrate of NME1ProteinHuman-GEM MAR06616Inferred only
- dTTP is a substrate of NME1ProteinHuman-GEM MAR06615Inferred only
- dTTP is a substrate of NME1ProteinHuman-GEM MAR07886Inferred only
- dTTP is a substrate of NME1ProteinHuman-GEM MAR07887Inferred only
- dTTP is a substrate of NME1ProteinHuman-GEM MAR04635Inferred only
- dTTP is a substrate of NME2ProteinHuman-GEM MAR06616Inferred only
- dTTP is a substrate of NME2ProteinHuman-GEM MAR04635Inferred only
- dTTP is a substrate of NME2ProteinHuman-GEM MAR06614Inferred only
- dTTP is a substrate of NME2ProteinHuman-GEM MAR06615Inferred only
- dTTP is a substrate of NME2ProteinHuman-GEM MAR07887Inferred only
- dTTP is a substrate of NME2ProteinHuman-GEM MAR07886Inferred only
- dTTP is a substrate of NME3ProteinHuman-GEM MAR06615Inferred only
- dTTP is a substrate of NME3ProteinHuman-GEM MAR06614Inferred only
- dTTP is a substrate of NME3ProteinHuman-GEM MAR06616Inferred only
- dTTP is a substrate of NME3ProteinHuman-GEM MAR07886Inferred only
- dTTP is a substrate of NME3ProteinHuman-GEM MAR04635Inferred only
- dTTP is a substrate of NME4ProteinHuman-GEM MAR06615Inferred only
- dTTP is a substrate of NME4ProteinHuman-GEM MAR06616Inferred only
- dTTP is a substrate of NME4ProteinHuman-GEM MAR06614Inferred only
- dTTP is a substrate of NME4ProteinHuman-GEM MAR07886Inferred only
- dTTP is a substrate of NME4ProteinHuman-GEM MAR04635Inferred only
- dTTP is a substrate of NME6ProteinHuman-GEM MAR06614Inferred only
- dTTP is a substrate of NME6ProteinHuman-GEM MAR06616Inferred only
- dTTP is a substrate of NME6ProteinHuman-GEM MAR07886Inferred only
- dTTP is a substrate of NME6ProteinHuman-GEM MAR06615Inferred only
- dTTP is a substrate of NME6ProteinHuman-GEM MAR04635Inferred only
- dTTP is a substrate of NME7ProteinHuman-GEM MAR06615Inferred only
- dTTP is a substrate of NME7ProteinHuman-GEM MAR06614Inferred only
- dTTP is a substrate of NME7ProteinHuman-GEM MAR04635Inferred only
- dTTP is a substrate of NME7ProteinHuman-GEM MAR07886Inferred only
- dTTP is a substrate of NME7ProteinHuman-GEM MAR06616Inferred only
- dTTP is a substrate of PKLRProteinHuman-GEM MAR06627Inferred only
- dTTP is a substrate of PKMProteinHuman-GEM MAR06627Inferred only
- dTTP is a substrate of POLA1ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLA2ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLBProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLD1ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLD2ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLD3ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLD4ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLEProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLE2ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLE3ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLE4ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLGProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLG2ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLHProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLIProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLKProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLLProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLMProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLNProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of POLQProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of REV3LProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of RFC5ProteinHuman-GEM MAR07160Inferred only
- dTTP is a substrate of SAMHD1ProteinRhea RHEA:80079Inferred only
- dTTP is a substrate of TENT4AProteinHuman-GEM MAR07160Inferred only
- dTTP is transported by SLC25A33ProteinHuman-GEM MAR20160Inferred only
- dTTP is transported by SLC25A33ProteinHuman-GEM MAR08301Inferred only
Reactions
29 reactions
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR01938CC BY 4.0Reference data
dTTP+waterdTDP+proton+phosphate(3-)
Catalysed by ENTPD1 or ENTPD3 or ENTPD8
Reaction pageReversibleBalancedEC 3.6.1.39extracellular space
Human-GEM MAR02125CC BY 4.0Reference data
0.505626L-alanine+0.35926L-arginine+0.279425L-asparagine+0.352607L-aspartate+20.704451ATP+0.020401CHEBI:1307929+0.011658a cardiolipin+0.039036CHEBI:17677+0.046571L-cysteine+0.013183CHEBI:16284+0.009442dCTP+0.009898CHEBI:16497+0.013091dTTP+0.275194D-glucopyranose 6-phosphate+0.385872L-glutamate(1-)+0.325996L-glutamine+0.538891glycine+0.036117GTP+20.650823water+0.126406CHEBI:15971+0.286078L-isoleucine+0.545544L-leucine+0.592114CHEBI:18019+0.153018L-methionine+0.1544631,2-diacyl-sn-glycero-3-phosphocholine(1+)+0.055374phosphatidylethanolamine+0.002914MAM02715c+0.259466L-phenylalanine+0.0233151-phosphatidyl-1D-myo-inositol+0.412484CHEBI:17203+0.005829phosphatidyl-L-serine+0.392525L-seryl residue+0.017486a sphingomyelin+0.31269CHEBI:16857+0.013306L-tryptophan+0.159671CHEBI:17895+0.053446UTP+0.352607L-valine20.650823ADP+20.650823proton+20.650823phosphate(3-)+MAM03970c
Reaction pageBlockedBalance undeterminablecytosol, nucleus
Human-GEM MAR04413CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR04635CC BY 4.0Reference data
CHEBI:16174+dTTPCHEBI:16284+dTDP
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6cytosol
Human-GEM MAR06614CC BY 4.0Reference data
CHEBI:16174+dTTPCHEBI:16284+dTDP
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR06615CC BY 4.0Reference data
CHEBI:16174+dTTPCHEBI:16284+dTDP
Catalysed by NME3 or NME4 or NME7 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6nucleus
Human-GEM MAR06616CC BY 4.0Reference data
dTDP+proton+phosphoenolpyruvic aciddTTP+pyruvate
Reaction pageReversibleBalancedEC 2.7.1.40cytosol
Human-GEM MAR06627CC BY 4.0Reference data
0.3CHEBI:16284+0.2dCTP+0.2CHEBI:16497+0.3dTTPMAM01721n+diphosphate(3-)
Catalysed by POLE4 & POLE3 or POLD1 & POLD2 & POLD3 & POLD4 or POLA1 & POLA2 or POLA1 & POLD1 & POLD2 & POLE2 & POLE & POLA2 & POLD3 & POLD4 & POLE4 & POLE3 or REV3L or POLQ or POLB or POLI or RFC5 or TENT4A or POLK or POLM and 5 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.7.7.7nucleus
Human-GEM MAR07160CC BY 4.0Reference data
dTTP+MAM01967c+protonMAM01751c+diphosphate(3-)
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR07696CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, nucleus
Human-GEM MAR07857CC BY 4.0Reference data
Catalysed by NME3 or NME4 or NME7 or AK9 or NME6 or NME1 or NME2
Reaction pageReversibleBalancedEC 2.7.4.6mitochondrial matrix
Human-GEM MAR07886CC BY 4.0Reference data
Other names
12 names
Resolves to: dTTP
- Also called
- 2'-deoxythymidine 5'-triphosphate2'-deoxythymidine triphosphate5'-TTPdeoxy-TTPdeoxythymidine 5'-triphosphatedeoxythymidine triphosphatedThd5'PPPpppdTthymidine 5'-triphosphateTHYMIDINE-5'-TRIPHOSPHATETTP
- Systematic name
- thymidine 5'-(tetrahydrogen triphosphate)