dTTP

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

95 compounds within 3 steps: 6 in 1, 16 in 2, 73 in 3

One step

CHEBI:16284Reach from here →
1. nucleoside-diphosphate kinase (dADP)
Catalysed by NME4, NME6, NME1, NME2 and 2 morecytosolOne of 3 routes
thymidineReach from here →
1. dTTP + H2O = thymidine + triphosphate + H(+)
Catalysed by SAMHD1
triphosphateReach from here →
1. dTTP + H2O = thymidine + triphosphate + H(+)
Catalysed by SAMHD1
dTDPReach from here →
1. DTTP Nucleotidohydrolase
Catalysed by ENTPD3, ENTPD1, ENTPD8extracellular spaceOne of 9 routes
phosphoenolpyruvic acidReach from here →
1. pyruvate kinase (dTDP)
Catalysed by PKM, PKLRcytosol
dTMPReach from here →
1. dTTP + H2O = dTMP + diphosphate + H(+)
Catalysed by ASMTL

Two steps

pyruvateReach from here →
1. DTTP Nucleotidohydrolase
2. pyruvate kinase (dTDP)
Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 1 moreextracellular space, cytosolOne of 8 routes
alpha-D-glucosamine 6-phosphateReach from here →
1. nucleoside-diphosphate kinase (dADP)
2. dATP:D-glucosamine 6-phosphotransferase
Catalysed by NME4, NME6, NME1, NME2 and 5 morecytosol

Three steps

CHEBI:1146900Reach from here →
Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol
2-hydroxybutyric acidReach from here →
Catalysed by and 7 more

keto-D-fructose 6-phosphateReach from here →

Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol

CHEBI:16174Reach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, NME4 and 5 moreextracellular space, cytosolOne of 25 routes

CHEBI:16497Reach from here →

Catalysed by PKM, PKLRcytosol

N-acetylneuraminate 9-phosphateReach from here →

Catalysed by PKM, PKLR, NANScytosol

CHEBI:28862Reach from here →

Catalysed by NME4, NME6, NME1, NME2 and 2 morecytosol, mitochondrial matrix

citric acidReach from here →

Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrixOne of 2 routes

isocitric acidReach from here →

Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrixOne of 2 routes

cis-aconitic acidReach from here →

Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrixOne of 2 routes

D-glucopyranose 6-phosphateReach from here →

Catalysed by NME4, NME6, NME1, NME2 and 6 morecytosol

2-deoxy-alpha-D-ribose 1-phosphateReach from here →

Catalysed by SAMHD1, TYMP

(2R)-2-phosphoglycerateReach from here →

Catalysed by PKM, PKLR, ENO1, ENO2 and 1 morecytosol

7,8-dihydroneopterin 3'-triphosphateReach from here →

Catalysed by SAMHD1, PTS

dCDPReach from here →

Catalysed by NME4, NME6, NME1, NME2 and 3 morecytosolOne of 2 routes

thiamine(1+) diphosphateReach from here →

Catalysed by NME4, NME6, NME1, NME2 and 3 morecytosol, mitochondrial matrixOne of 2 routes

ENTPD3

, ENTPD1

, ENTPD8

, PKM

extracellular space, cytosol

One of 2 routes

6-pyruvoyl-5,6,7,8-tetrahydropterinReach from here →

Catalysed by SAMHD1, PTS

acetoacetateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

acetylpyruvateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

all-trans-retinoic acidReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 7 moreextracellular space, cytosolOne of 2 routes

D-threo-isocitrateReach from here →

Catalysed by PKM, PKLR, SLC25A1, ACO1 and 1 morecytosol, mitochondrial matrixOne of 3 routes

(S)-malateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosolOne of 13 routes

trans-aconitateReach from here →

Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

thioredoxin dithiolReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, NME4 and 10 moreextracellular space, cytosol, mitochondrial matrixOne of 4 routes

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol, mitochondrial matrix

CHEBI:16332Reach from here →

Catalysed by NME4, NME6, NME1, NME2 and 9 morecytosol

cis-aconitateReach from here →

Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

oxaloacetateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol, mitochondrial matrixOne of 6 routes

(S)-lactateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 6 moreextracellular space, cytosol

2-oxobutanoateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

2-oxoglutaramateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

D-erythrose 4-phosphateReach from here →

Catalysed by NME4, NME6, NME1, NME2 and 9 morecytosol

oxalic acidReach from here →

Catalysed by PKM, PKLR, SLC25A1cytosol, mitochondrial matrixOne of 9 routes

7,8-dihydroneopterinReach from here →

Catalysed by SAMHD1, PTS, ALPLextracellular spaceOne of 2 routes

(R)-3-hydroxybutyric acidReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 7 moreextracellular space, cytosolOne of 2 routes

2'-deoxyguanosineReach from here →

Catalysed by SAMHD1, TYMP, PNP

3-hydroxypyruvateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

itaconateReach from here →

Catalysed by PKM, PKLR, SLC25A1, ACOD1cytosol, mitochondrial matrix

aceneuramateReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 2 moreextracellular space, cytosol

5'-deoxyadenosineReach from here →

Catalysed by ENTPD3, ENTPD1, ENTPD8, PKM and 3 moreextracellular space, cytosol

2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →

Catalysed by NME4, NME6, NME1, NME2 and 5 morecytosol, mitochondrial matrix