Compound

2-phenylethylamine

A phenylethylamine having the phenyl substituent at the 2-position.

Definition from ChEBI (CHEBI:18397), read 2026-09-23. CC BY 4.0.

CHEBI:18397ChEBI

Open in the graph

What it touches on the way

Mechanistic reach

4 entities

4 entities reached.

0 reported hops4 assembled from the scaffold

What the reference databases state

Chemical structure

(R)-octopamine has the functional parent 2-phenylethylamineCompoundChEBI CHEBI:141486Inferred only

Statements

7 statements

7 statements · 1 reference database · Subject: 2-phenylethylamine · Sources: Human-GEM

Order

2-phenylethylamine is converted to 2-phenylacetaldehydeCompoundHuman-GEM MAR04682Inferred only
L-phenylalanine is converted to 2-phenylethylamineCompoundHuman-GEM MAR04681Inferred only
2-phenylethylamine is metabolised by MAOAProteinHuman-GEM MAR04682Inferred only
2-phenylethylamine is metabolised by MAOBProteinHuman-GEM MAR04682Inferred only
2-phenylethylamine is a substrate of AOC1ProteinHuman-GEM MAR04682Inferred only
2-phenylethylamine is a substrate of AOC2ProteinHuman-GEM MAR04682Inferred only
2-phenylethylamine is a substrate of AOC3ProteinHuman-GEM MAR04682Inferred only

Reactions

11 reactions

proton+L-phenylalaninecarbon dioxide+2-phenylethylamine
Catalysed by DDC
Reaction pageLeft to rightBalancedEC 4.1.1.28GO:0005829
Human-GEM MAR04681CC BY 4.0Reference data
water+dioxygen+2-phenylethylamineproton+hydrogen peroxide+ammonium+2-phenylacetaldehyde
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21GO:0005829
Human-GEM MAR04682CC BY 4.0Reference data
proton+NADPH(4-)+dioxygen+2-phenylethylaminewater+NADP(3-)+MAM03099c
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR11224CC BY 4.0Reference data
L-phenylalanine+hydron2-phenylethylamine+carbon dioxide
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:19717CC BY 4.0Reference data
CHEBI:18177+water2-phenylethylamine+acetate
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:23952CC BY 4.0Reference data
2-phenylethylamine+dioxygen+water2-phenylacetaldehyde+hydrogen peroxide+ammonium
Catalysed by AOC2 or MAOA or MAOB or AOC3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:25265CC BY 4.0Reference data
2-phenylethylamine2-phenylethylamine
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:29743CC BY 4.0Reference data
2-phenylethylamine+A+water2-phenylacetaldehyde+AH2+ammonium
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:36723CC BY 4.0Reference data
2-phenylethylamine+pyruvate2-phenylacetaldehyde+L-alanine
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:64284CC BY 4.0Reference data
2-phenylethylamine+acetyl-CoACHEBI:18177+coenzyme A(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:66148CC BY 4.0Reference data
CHEBI:15688+2-phenylethylamineCHEBI:143110+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:85475CC BY 4.0Reference data

Other names

9 names

Resolves to: 2-phenylethylamine

Also called: benzeneethanaminebeta-aminoethylbenzenebeta-phenethylaminebeta-PhenylethylaminePhenethylaminePhenylethylamineβ-aminoethylbenzeneβ-phenethylamine
Systematic name: 2-phenylethanamine