S-methyl-5'-thioadenosine

1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase

Catalysed by MTAPcytosolOne of 2 routes

1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

Catalysed by SRM

1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)

Catalysed by SRM

1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase

Catalysed by MTAPcytosolOne of 2 routes

1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
2. acetyl-CoA:putrescine N-acetyltransferase

Catalysed by SRM, SAT1, SAT2cytosol

1. S-methyl-5'-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase
2. adenosine:phosphate alpha-D-ribosyltransferase

Catalysed by MTAP, PNPcytosol

1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
2. acetyl-CoA:putrescine N-acetyltransferase
3. Carnitine O-Palmitoyltransferase

Catalysed by SRM, SAT1, SAT2, CPT1A and 2 morecytosolOne of 244 routes

1. S-adenosyl 3-(methylsulfanyl)propylamine + putrescine = S-methyl-5'-thioadenosine + spermidine + H(+)
2. Putrescine Export via Putrescine/Arginine Antiporter
3. N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)