cis-aconitic acid

Three steps

• hypochlorous acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by SLC25A1, SLC26A6, LPOmitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLC25A1, SLC26A6, SLC12A2, SLC12A1mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• folic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Folate Transport by Oats

  Catalysed by SLC25A1, SLC25A10, SLC22A8, SLC22A7mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• CHEBI:28862Reach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dADP to dATP conversion

  Catalysed by SLC25A1, PKM, PKLRmitochondrial matrix, cytosolOne of 13 routes

• a dicarboxylateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A35, SLC25A34mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycocholateReach from here →
  1. cis-aconitate carboxy-lyase
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)

  Catalysed by ACOD1, SUGCT, SLC22A24mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• glycolateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glycolate + NADP(+) = glyoxylate + NADPH + H(+)

  Catalysed by SLC25A1, CLYBL, GRHPRmitochondrial matrix, cytosol

• hydrogen sulfideReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and thiosulfate (cytosol to mitochondria)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by SLC25A1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• D-aspartateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. L-Aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC25A1, GOT2mitochondrial matrix, cytosolOne of 7 routes

• acetateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of acetate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• oxalateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A14, SLC26A2 and 3 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• formic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of formate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 4 moremitochondrial matrix, cytosol, extracellular spaceOne of 4 routes

• propionic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of propanoate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• butyric acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. transport of butyrate and pyruvate (cytosol to extracellular)

  Catalysed by SLC25A1, ME2, ME3, SLC16A4 and 5 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• malonic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by SLC25A1, SLC25A10mitochondrial matrix, cytosolOne of 6 routes

• adipic acidReach from here →
  1. cis-aconitate carboxy-lyase
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by ACOD1, SUGCTmitochondrial matrix

• 3-hydroxypyruvic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. L-Serine:pyruvate aminotransferase

  Catalysed by SLC25A1, ME2, ME3, AGXTmitochondrial matrix, cytosolOne of 2 routes

• (S)-dihydroorotateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
  3. (S)-dihydroorotate + a quinone = orotate + a quinol

  Catalysed by SLC25A1, SDHB, SDHA, DHODHmitochondrial matrix, cytosol

• 4-hydroxy-2-oxoglutaric acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and OAA (cytosol to mitochondria)
  3. D-aspartate:2-oxoglutarate aminotransferase

  Catalysed by SLC25A1, GOT2mitochondrial matrix, cytosol

• (2R,3R)-tartrateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLC25A1, SLC25A10, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-oxopropanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosol

• D-serineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. D-serine = pyruvate + NH4(+)

  Catalysed by SLC25A1, ME2, ME3, SRRmitochondrial matrix, cytosol

• N-acetylneuraminateReach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. N-acetylneuraminate synthase
  3. N-acetylneuraminate 9-phosphate + H2O = N-acetylneuraminate + phosphate

  Catalysed by SLC25A1, NANS, NANPmitochondrial matrix, cytosol

• 3-(4-hydroxyphenyl)pyruvateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• taurocholateReach from here →
  1. cis-aconitate carboxy-lyase
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

  Catalysed by ACOD1, SUGCT, SLC22A24, SLC22A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:36882Reach from here →
  1. cis-aconitate carboxy-lyase
  2. Itaconate:CoA ligase (GDP-forming)
  3. (3S)-citramalyl-CoA hydro-lyase (itaconyl-CoA-forming)

  Catalysed by ACOD1, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix

• D-glucopyranose 6-phosphateReach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. dATP:pyruvate 2-O-phosphotransferase
  3. dATP:D-glucose 6-phosphotransferase

  Catalysed by SLC25A1, PKM, PKLR, HK1 and 3 moremitochondrial matrix, cytosol

• (R)-lactic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC25A1, ME2, ME3, LDHDmitochondrial matrix, cytosol

• (S)-lactic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (S)-Lactate:NAD+ oxidoreductase

  Catalysed by SLC25A1, ME2, ME3, LDHB and 1 moremitochondrial matrix, cytosolOne of 5 routes

• 2-iminopropanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by SLC25A1, ME2, ME3, RIDAmitochondrial matrix, cytosol

• N-acetyl-beta-neuraminic acidReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SLC25A1, ME2, ME3, NPLmitochondrial matrix, cytosolOne of 2 routes

• taurineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC25A1, SLC26A6, SLC6A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate + a quinone = enol-oxaloacetate + a quinol
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by SLC25A1, SDHB, SDHA, NQO2mitochondrial matrix, cytosol

• a 3-acylpyruvateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SLC25A1, ME2, ME3, FAHD1mitochondrial matrix, cytosol

• succinyl-CoAReach from here →
  1. cis-aconitate carboxy-lyase
  2. Itaconate:CoA ligase (GDP-forming)
  3. itaconate + succinyl-CoA = itaconyl-CoA + succinate

  Catalysed by ACOD1, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrix

• glycineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosolOne of 18 routes

• glutaryl-CoAReach from here →
  1. cis-aconitate carboxy-lyase
  2. Itaconate:CoA ligase (GDP-forming)
  3. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate

  Catalysed by ACOD1, SUCLG1, SUCLG2, SUCLA2 and 1 moremitochondrial matrixOne of 5 routes

• prostaglandin F2alphaReach from here →
  1. cis-aconitate carboxy-lyase
  2. itaconate + glutaryl-CoA = itaconyl-CoA + glutarate
  3. prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

  Catalysed by ACOD1, SUGCT, SLC22A8mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(N(omega)-L-arginino)succinateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by SLC25A1, FH, ASLmitochondrial matrix, cytosolOne of 2 routes

• 2-oxoadipateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. L-2-aminoadipate + glyoxylate = 2-oxoadipate + glycine

  Catalysed by SLC25A1, CLYBL, AADATmitochondrial matrix, cytosol

• N(6)-(1,2-dicarboxyethyl)-AMPReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate hydro-lyase (fumarate-forming)
  3. N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

  Catalysed by SLC25A1, FH, ADSL, TNRC6Bmitochondrial matrix, cytosolOne of 2 routes

• dGMPReach from here →
  1. transport of cis-aconitate and PEP (cytosol to mitochondria)
  2. dGTP:pyruvate 2-O-phosphotransferase
  3. 2-Deoxyguanosine 5-Triphosphate Pyrophosphohydrolase

  Catalysed by SLC25A1, PKM, PKLR, ITPAmitochondrial matrix, cytosol, extracellular space

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by SLC25A1, ME2, ME3, MPSTmitochondrial matrix, cytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by SLC25A1, ME2, ME3, AGXT2mitochondrial matrix, cytosol

• guanidinoacetateReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. transport of chloride and oxalate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC25A1, SLC26A6mitochondrial matrix, cytosol, extracellular space

• L-methionineReach from here →
  1. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

  Catalysed by SLC25A1, ME2, ME3, TYW1B and 1 moremitochondrial matrix, cytosolOne of 3 routes