CHEBI:36882

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

185 compounds within 3 steps: 1 in 1, 41 in 2, 143 in 3

One step

pyruvateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
Catalysed by CLYBLmitochondrial matrix

Two steps

2-hydroxybutyric acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)
Catalysed by CLYBL, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes
acetoacetateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
Catalysed by CLYBLmitochondrial matrix, cytosolOne of 4 routes
acetylpyruvateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. acetylpyruvate + H2O = acetate + pyruvate + H(+)
Catalysed by CLYBL, FAHD1mitochondrial matrix
all-trans-retinoic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. transport of pyruvate and retinoate (cytosol to extracellular)
Catalysed by CLYBL, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes
(S)-malateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
Catalysed by CLYBL, ME2mitochondrial matrixOne of 2 routes
2-methyl-3-oxopropanoic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Catalysed by CLYBL, AGXT2mitochondrial matrix
oxaloacetateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. Pyruvate:carbon-dioxide ligase (ADP-forming)
Catalysed by CLYBL, PCmitochondrial matrixOne of 3 routes
(S)-lactateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
Catalysed by CLYBL, LDHA, LDHB, LDHC and 2 moremitochondrial matrix
2-oxobutanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
Catalysed by CLYBL, AGXT2mitochondrial matrix
2-oxoglutaramateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. L-Glutamine:pyruvate aminotransferase
Catalysed by CLYBL, KYAT1mitochondrial matrix, cytosolOne of 2 routes
3-fumarylpyruvateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. 3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)
Catalysed by CLYBL, FAHD1mitochondrial matrix
(R)-3-hydroxybutyric acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)
Catalysed by CLYBL, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes
3-hydroxypyruvateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. L-serine + pyruvate = 3-hydroxypyruvate + L-alanine
Catalysed by CLYBL, AGXTmitochondrial matrix
aceneuramateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate
Catalysed by CLYBL, NPLmitochondrial matrix
5'-deoxyadenosineReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
Catalysed by CLYBL, TYW1B, TYW1mitochondrial matrix
dTDPReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. pyruvate kinase (dTDP)
Catalysed by CLYBL, PKM, PKLRmitochondrial matrix, cytosol
5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by CLYBL, AGXT2mitochondrial matrix
5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine
Catalysed by CLYBL, AGXT2mitochondrial matrix
5-(3-methylguanidino)-2-oxopentanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine
Catalysed by CLYBL, AGXT2mitochondrial matrix
acetateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. transport of acetate and pyruvate (cytosol to extracellular)
Catalysed by CLYBL, SLC16A4, SLC16A5, SLC16A3 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes
formic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. transport of formate and pyruvate (cytosol to extracellular)
Catalysed by CLYBL, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes
propionic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. transport of propanoate and pyruvate (cytosol to extracellular)
Catalysed by CLYBL, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes
butyric acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. transport of butyrate and pyruvate (cytosol to extracellular)
Catalysed by CLYBL, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes
3-hydroxypyruvic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. L-Serine:pyruvate aminotransferase
Catalysed by CLYBL, AGXTmitochondrial matrix, cytosolOne of 2 routes
3-oxopropanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
Catalysed by CLYBL, AGXT2mitochondrial matrix
D-serineReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. D-serine = pyruvate + NH4(+)
Catalysed by CLYBL, SRRmitochondrial matrix
(R)-lactic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (R)-Lactate:NAD+ oxidoreductase
Catalysed by CLYBL, LDHDmitochondrial matrix, cytosol
(S)-lactic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (S)-Lactate:NAD+ oxidoreductase
Catalysed by CLYBL, LDHB, LDHAL6Bmitochondrial matrixOne of 5 routes
2-iminopropanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. 2-iminopropanoate + H2O = pyruvate + NH4(+)
Catalysed by CLYBL, RIDAmitochondrial matrix
phosphoenolpyruvic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. pyruvate kinase (dTDP)
Catalysed by CLYBL, PKM, PKLRmitochondrial matrix, cytosol
N-acetyl-beta-neuraminic acidReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by CLYBL, NPLmitochondrial matrix, cytosol
a 3-acylpyruvateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)
Catalysed by CLYBL, FAHD1mitochondrial matrix
2-oxo-3-sulfanylpropanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
Catalysed by CLYBL, MPSTmitochondrial matrix
2-methyl-3-oxopropanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
Catalysed by CLYBL, AGXT2mitochondrial matrix
L-methionineReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
Catalysed by CLYBL, TYW1B, TYW1mitochondrial matrix
L-alanineReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Catalysed by CLYBL, AGXT2mitochondrial matrixOne of 18 routes
(3S)-citramalyl-CoAReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA
Catalysed by CLYBLmitochondrial matrix
5-amino-2-oxopentanoateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
Catalysed by CLYBL, AGXT2mitochondrial matrix
(4R)-4-hydroxy-2-oxoglutarateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by CLYBL, HOGA1mitochondrial matrix
(4S)-4-hydroxy-2-oxoglutarateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate
Catalysed by CLYBL, HOGA1mitochondrial matrix
2-(1-hydroxyethyl)thiamine diphosphateReach from here →
1. (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
2. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Catalysed by CLYBL, PDHA1, PDHB, PDHA2mitochondrial matrix

CHEBI:36882

One step

Two steps

Three steps