Loading the page.
Proteins/UNIPROT:Q9GZT4
Pyridoxal-5'-phosphate (PLP)-dependent enzyme that catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. In addition to racemization, has dehydratase activity towards both L-serine and D-serine, a two-step reaction in which the hydroxyl group of serine is eliminated to produce aminoacrylate (2-aminoprop-2-enoate), and then the aminoacrylate (an unstable intermediate) is deaminated by nonenzymatic hydrolysis to produce pyruvate (By similarity)..
Function from UniProtKB (Q9GZT4), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
34 statements
34 statements · 6 reference databases · Subject: SRR · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
8 reactions
L-seryl residueproton+ammonium+pyruvate
Catalysed by SDS or SDSL or SRR
Reaction pageLeft to rightBalancedEC 4.3.1.17, 4.3.1.19cytosol
Human-GEM MAR03883CC BY 4.0Reference data
2-aminoacrylic acid+waterproton+ammonium+pyruvate
Catalysed by SDS
4 names
Resolves to: SRR
Reaction pageLeft to rightBalancedEC 4.3.1.17, 4.3.1.19cytosol
Human-GEM MAR03974CC BY 4.0Reference data
L-seryl residue2-aminoacrylic acid+water
Catalysed by SDS or SDSL or SRR
Reaction pageLeft to rightBalancedEC 4.3.1.17, 4.3.1.19cytosol
Human-GEM MAR04200CC BY 4.0Reference data
Catalysed by SRR
Reaction pageDirection not assertedBalanced
Rhea RHEA:10980CC BY 4.0Reference data
Catalysed by SRR
Reaction pageDirection not assertedBalanced
Rhea RHEA:13977CC BY 4.0Reference data
L-seryl residuepyruvate+ammonium
Catalysed by SDS or SDSL or SRR
Reaction pageDirection not assertedBalanced
Rhea RHEA:19169CC BY 4.0Reference data
L-seryl residue2-aminoprop-2-enoate+water
Catalysed by SRR
Reaction pageDirection not assertedBalanced
Rhea RHEA:40663CC BY 4.0Reference data
D-serine2-aminoprop-2-enoate+water
Catalysed by SRR
Reaction pageDirection not assertedBalanced
Rhea RHEA:43008CC BY 4.0Reference data