(S)-dihydroorotate

1. (S)-dihydroorotate amidohydrolase

Catalysed by CADcytosol

1. (S)-dihydroorotate:NAD+ oxidoreductase

Catalysed by DHODHcytosol

1. (S)-dihydroorotate + a quinone = orotate + a quinol

Catalysed by DHODH

1. (S)-dihydroorotate + a quinone = orotate + a quinol

Catalysed by DHODH

1. (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)

Catalysed by CAD

1. (S)-dihydroorotate + a quinone = orotate + a quinol
2. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

Catalysed by DHODH, CYC1, UQCRFS1outer side of the membraneOne of 7 routes

1. (S)-dihydroorotate:NAD+ oxidoreductase
2. Orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase

Catalysed by DHODH, UMPScytosol

1. (S)-dihydroorotate amidohydrolase
2. carbamoyl-phosphate:L-aspartate carbamoyltransferase
3. acetyl-CoA:L-aspartate N-acetyltransferase

Catalysed by CAD, NAT8Lcytosol, mitochondrial matrix

1. (S)-dihydroorotate + a quinone = orotate + a quinol
2. a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)
3. 2 a quinone + NADPH + H(+) = 2 a 1,4-benzosemiquinone + NADP(+)

Catalysed by DHODH, and 3 more