N-acetyl-beta-neuraminic acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

254 compounds within 3 steps: 4 in 1, 93 in 2, 157 in 3

One step

pyruvateReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by NPLcytosol
aldehydo-N-acetyl-D-mannosamineReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
Catalysed by NPLcytosol
N-glycoloylneuraminateReach from here →
1. CMP-N-acetylneuraminate monooxygenase (N-acetylneuraminate)
No catalyst recordedcytosol
CMP-N-acetyl-beta-neuraminateReach from here →
1. CTP:N-acetylneuraminate cytidylyltransferase
Catalysed by CMASnucleusOne of 2 routes

Two steps

2-hydroxybutyric acidReach from here →
1. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)
Catalysed by NPL, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes
an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivativeReach from here →
1. CTP:N-acetylneuraminate cytidylyltransferase
2. a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl derivative + CMP + H(+)
Catalysed by CMAS, ST6GAL1

, ST6GAL2

nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivativeReach from here →

Catalysed by CMAS, ST3GAL3, ST3GAL4, ST3GAL6nucleus

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivativeReach from here →

Catalysed by CMAS, ST3GAL4nucleus

acetoacetateReach from here →

Catalysed by NPLcytosol, mitochondrial matrixOne of 4 routes

an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by CMAS, ST3GAL1, ST3GAL4, ST3GAL2nucleus

an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivativeReach from here →

Catalysed by CMAS, ST8SIA3, ST8SIA1nucleus

a globoside MSGGReach from here →

Catalysed by CMAS, ST3GAL2nucleus

a globoside DSGGReach from here →

Catalysed by CMAS, ST6GALNAC3, ST6GALNAC6nucleus

a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivativeReach from here →

Catalysed by CMAS, ST6GALNAC1, ST6GALNAC2nucleus

a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E))Reach from here →

Catalysed by CMAS, ST3GAL6nucleus

an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivativeReach from here →

Catalysed by CMAS, ST6GALNAC3, ST6GALNAC4nucleus

acetylpyruvateReach from here →

Catalysed by NPL, FAHD1cytosol

all-trans-retinoic acidReach from here →

Catalysed by NPL, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

(S)-malateReach from here →

Catalysed by NPL, ME2cytosolOne of 2 routes

N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-D-galactosamineReach from here →

Catalysed by CMAS, ST6GALNAC4nucleus

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by NPL, AGXT2cytosol, mitochondrial matrix

oxaloacetateReach from here →

Catalysed by NPL, PCcytosol, mitochondrial matrixOne of 3 routes

(S)-lactateReach from here →

Catalysed by NPL, LDHA, LDHB, LDHC and 2 morecytosol

2-oxobutanoateReach from here →

Catalysed by NPL, AGXT2cytosol

2-oxoglutaramateReach from here →

Catalysed by NPL, KYAT1cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by NPL, FAHD1cytosol

(R)-3-hydroxybutyric acidReach from here →

Catalysed by NPL, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

3-hydroxypyruvateReach from here →

Catalysed by NPL, AGXTcytosol

aceneuramateReach from here →

Catalysed by NPLcytosolOne of 2 routes

5'-deoxyadenosineReach from here →

Catalysed by NPL, TYW1B, TYW1cytosol

dTDPReach from here →

Catalysed by NPL, PKM, PKLRcytosol

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by NPL, AGXT2cytosol

5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by NPL, AGXT2cytosol

5-(3-methylguanidino)-2-oxopentanoateReach from here →

Catalysed by NPL, AGXT2cytosol

an alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivativeReach from here →

Catalysed by CMAS, ST8SIA3nucleus

alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAcReach from here →

Catalysed by CMAS, ST8SIA3nucleus

CMP-N-acetyl-9-O-acetyl-beta-neuraminateReach from here →

Catalysed by CMAS, CASD1nucleus

CMP-N-acetyl-7-O-acetyl-beta-neuraminateReach from here →

Catalysed by CMAS, CASD1nucleus

acetateReach from here →

Catalysed by NPL, SLC16A4, SLC16A5, SLC16A3 and 2 morecytosol, extracellular spaceOne of 2 routes

formic acidReach from here →

Catalysed by NPL, SLC16A4, SLC16A5, SLC16A7 and 2 morecytosol, extracellular spaceOne of 2 routes

propionic acidReach from here →

Catalysed by NPL, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

butyric acidReach from here →

Catalysed by NPL, SLC16A4, SLC16A5, SLC16A3 and 3 morecytosol, extracellular spaceOne of 2 routes

3-hydroxypyruvic acidReach from here →

Catalysed by NPL, AGXTcytosolOne of 2 routes

3-oxopropanoateReach from here →

Catalysed by NPL, AGXT2cytosol

D-serineReach from here →

Catalysed by NPL, SRRcytosol

(R)-lactic acidReach from here →

Catalysed by NPL, LDHDcytosol

(S)-lactic acidReach from here →

Catalysed by NPL, LDHB, LDHAL6Bcytosol, mitochondrial matrixOne of 5 routes

2-iminopropanoateReach from here →

Catalysed by NPL, RIDAcytosol

phosphoenolpyruvic acidReach from here →

Catalysed by NPL, PKM, PKLRcytosol

N-acetyl-D-glucosamineReach from here →

Catalysed by NPL, RENBPcytosol