Compound

(S)-dihydroorotate

A dihydroorotate that is the conjugate base of (S)-dihydroorotic acid.

Definition from ChEBI (CHEBI:30864), read 2026-09-23. CC BY 4.0.

CHEBI:30864ChEBI

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Structure

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A generated conformer of (S)-dihydroorotate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C5H5N2O4
Mass: 157.105 g/mol
Charge: -1
InChIKey: UFIVEPVSAGBUSI-REOHCLBHSA-M
SMILES: O=C1C[C@@H](C(=O)[O-])NC(=O)N1
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

2 entities

2 entities reached.

0 reported hops2 assembled from the scaffold

What the reference databases state

Statements

10 statements

10 statements · 2 reference databases · Subject: (S)-dihydroorotate · Sources: Human-GEM, Rhea

Order

N-carbamoyl-L-aspartate is converted to (S)-dihydroorotateCompoundRhea RHEA:24296Inferred only
(S)-dihydroorotate is converted to N-carbamoyl-L-aspartateCompoundRhea RHEA:24296Inferred only
N-carbamoyl-L-aspartic acid is converted to (S)-dihydroorotateCompoundHuman-GEM MAR04608Inferred only
(S)-dihydroorotate is converted to N-carbamoyl-L-aspartic acidCompoundHuman-GEM MAR04608Inferred only
orotic acid is converted to (S)-dihydroorotateCompoundHuman-GEM MAR04575Inferred only
(S)-dihydroorotate is converted to orotic acidCompoundHuman-GEM MAR04575Inferred only
(S)-dihydroorotate is a substrate of CADProteinHuman-GEM MAR04608Inferred only
(S)-dihydroorotate is a substrate of CADProteinRhea RHEA:24296Inferred only
(S)-dihydroorotate is a substrate of DHODHProteinRhea RHEA:30187Inferred only
(S)-dihydroorotate is a substrate of DHODHProteinHuman-GEM MAR04575Inferred only

Reactions

13 reactions

(S)-dihydroorotate+CHEBI:17621orotic acid+FMNH2
Catalysed by DHODH
Reaction pageReversibleBalancedEC 1.3.5.2, 1.3.1.14GO:0005829
Human-GEM MAR04575CC BY 4.0Reference data
(S)-dihydroorotate+waterproton+N-carbamoyl-L-aspartic acid
Catalysed by CAD
Reaction pageReversibleBalancedEC 3.5.2.3GO:0005829
Human-GEM MAR04608CC BY 4.0Reference data
0.0043(S)-dihydroorotate+0.0014MAM00569c+0.0022(2R)-3-phosphoglycerate+0.0025MAM00916c+0.0002CHEBI:15351+0.0033ADP+0.00462-oxoglutarate(2-)+0.0404L-alanine+0.0002AMP+0.0015L-arginine+0.0012L-asparagine+0.0865L-aspartate+0.0271ATP+0.0034citric acid+0.0234CHEBI:1146900+0.0052CHEBI:17677+0.0005L-cysteine+0.0001MAM01639c+0.0002dCMP+0.0094CHEBI:16108+0.0088MAM01841c+0.0006keto-D-fructose 6-phosphate+0.0028fumaric acid+0.0008CHEBI:29052+0.0002GDP+0.0039D-glucopyranose 6-phosphate+0.3694L-glutamate(1-)+0.0998L-glutamine+0.0215glycine+0.0001GMP+0.0179CHEBI:16856+0.0001glutathione disulfide+0.0039GTP+0.0024CHEBI:15971+0.0002isocitric acid+0.0102L-isoleucine+0.0102L-leucine+0.0029CHEBI:18019+0.0081(S)-malate+0.0037L-methionine+0.0029NAD(+)+0.0004NADH(2-)+0.0002NADP(3-)+0.0004NADPH(4-)+0.0049L-phenylalanine+0.01023-phenylpyruvate+0.0071CHEBI:17203+0.034pyruvate+0.0002CHEBI:17797+0.0282L-seryl residue+0.0388CHEBI:16857+0.001L-tryptophan+0.0054CHEBI:17895+0.0008UDP+0.0088MAM03108c+0.0006UDP-alpha-D-glucuronate+0.052CHEBI:16264+0.0102UTP+0.0088L-valineMAM10015c
Reaction pageLeft to rightBalance undeterminableGO:0005829
Human-GEM MAR10064CC BY 4.0Reference data
(S)-dihydroorotate+NAD(1-)orotate+NADH(2-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:13513CC BY 4.0Reference data
(S)-dihydroorotate+NADP(3-)orotate+NADPH(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:14861CC BY 4.0Reference data
(S)-dihydroorotate+Aorotate+AH2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:18073CC BY 4.0Reference data
(S)-dihydroorotate+waterN-carbamoyl-L-aspartate+hydron
Catalysed by CAD
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:24296CC BY 4.0Reference data
(S)-dihydroorotate+CHEBI:61683CHEBI:61682+orotate
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:28687CC BY 4.0Reference data
(S)-dihydroorotate+a ubiquinoneorotate+a ubiquinol
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:28691CC BY 4.0Reference data
(S)-dihydroorotate+a menaquinoneorotate+a menaquinol
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:29195CC BY 4.0Reference data
(S)-dihydroorotate+CHEBI:44027orotate+CHEBI:61684
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:29199CC BY 4.0Reference data
(S)-dihydroorotate+fumaric acidorotate+succinate(2-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:30059CC BY 4.0Reference data

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Other names

3 names

Resolves to: (S)-dihydroorotate

Also called: (S)-4,5-dihydroorotate4,5-dihydro-L-orotate
Systematic name: (4S)-2,6-dioxohexahydropyrimidine-4-carboxylate