Compound

2-oxo-3-sulfanylpropanoate

The conjugate base of 3-mercaptopyruvic acid.

Definition from ChEBI (CHEBI:57678), read 2026-09-23. CC BY 4.0.

CHEBI:57678ChEBI

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Structure

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A generated conformer of 2-oxo-3-sulfanylpropanoate — one low-energy arrangement PubChem computed, not a measured structure. Hydrogens are not drawn; the formula counts them.

Class: Organic compound, anion
Formula: C3H3O3S
Mass: 119.121 g/mol
Charge: -1
InChIKey: OJOLFAIGOXZBCI-UHFFFAOYSA-M
SMILES: O=C([O-])C(=O)CS
Look it up: ChEBI PubChem By InChIKey

Identity from ChEBI, geometry from PubChem. Not evidence.

What it touches on the way

Mechanistic reach

11 entities

11 entities reached.

0 reported hops11 assembled from the scaffold

What the reference databases state

Statements

28 statements

28 statements · 2 reference databases · Subject: 2-oxo-3-sulfanylpropanoate · Sources: Human-GEM, Rhea

Order

3-mercaptolactic acid is converted to 2-oxo-3-sulfanylpropanoateCompoundHuman-GEM MAR06519Inferred only
2-oxo-3-sulfanylpropanoate is converted to 3-mercaptolactic acidCompoundHuman-GEM MAR06519Inferred only
D-cysteine is converted to 2-oxo-3-sulfanylpropanoateCompoundRhea RHEA:78791Inferred only
2-oxo-3-sulfanylpropanoate is converted to L-cysteineCompoundHuman-GEM MAR03912Inferred only
2-oxo-3-sulfanylpropanoate is converted to L-cysteineCompoundHuman-GEM MAR08684Inferred only
L-cysteine is converted to 2-oxo-3-sulfanylpropanoateCompoundHuman-GEM MAR08684Inferred only
L-cysteine is converted to 2-oxo-3-sulfanylpropanoateCompoundRhea RHEA:17441Inferred only
L-cysteine is converted to 2-oxo-3-sulfanylpropanoateCompoundRhea RHEA:61256Inferred only
L-cysteine is converted to 2-oxo-3-sulfanylpropanoateCompoundHuman-GEM MAR03912Inferred only
2-oxo-3-sulfanylpropanoate is converted to L-cysteineCompoundRhea RHEA:17441Inferred only
2-oxo-3-sulfanylpropanoate is converted to L-cysteineCompoundRhea RHEA:61256Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of AADATProteinRhea RHEA:69104Inferred only

Show the remaining 16

2-oxo-3-sulfanylpropanoate is a substrate of CISD1ProteinRhea RHEA:17441Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of GOT1ProteinRhea RHEA:17441Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of GOT1ProteinHuman-GEM MAR03912Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of GOT2ProteinHuman-GEM MAR08684Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of GOT2ProteinHuman-GEM MAR03912Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of LDHAL6AProteinHuman-GEM MAR06519Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of LDHAL6BProteinHuman-GEM MAR06519Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of LDHBProteinHuman-GEM MAR06519Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of LDHCProteinHuman-GEM MAR06519Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of MPSTProteinRhea RHEA:21740Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of MPSTProteinHuman-GEM MAR03928Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of MPSTProteinHuman-GEM MAR06518Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of MPSTProteinHuman-GEM MAR06515Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of TSTProteinHuman-GEM MAR06515Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of TSTProteinHuman-GEM MAR06518Inferred only
2-oxo-3-sulfanylpropanoate is a substrate of TSTProteinHuman-GEM MAR03928Inferred only

Reactions

16 reactions

2-oxoglutarate(2-)+L-cysteineL-glutamate(1-)+2-oxo-3-sulfanylpropanoate
Catalysed by GOT1 or GOT2
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.3cytosol
Human-GEM MAR03912CC BY 4.0Reference data
proton+2-oxo-3-sulfanylpropanoate+sulfitethiosulfate+pyruvate
Catalysed by MPST or TST
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR03928CC BY 4.0Reference data
2-oxo-3-sulfanylpropanoate+sulfitepyruvate+thiosulfate
Catalysed by MPST or TST
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR06515CC BY 4.0Reference data
hydrogen cyanide+2-oxo-3-sulfanylpropanoateproton+pyruvate+thiocyanate
Catalysed by MPST or TST
Reaction pageLeft to rightBalancedEC 2.8.1.2cytosol
Human-GEM MAR06518CC BY 4.0Reference data
3-mercaptolactic acid+NAD(+)proton+2-oxo-3-sulfanylpropanoate+NADH(2-)
Catalysed by LDHB or LDHC or LDHAL6A or LDHAL6B
Reaction pageReversibleBalancedEC 1.1.1.27cytosol
Human-GEM MAR06519CC BY 4.0Reference data
2-oxoglutarate(2-)+L-cysteineL-glutamate(1-)+2-oxo-3-sulfanylpropanoate
Catalysed by GOT2
Reaction pageReversibleBalancedEC 2.6.1.1mitochondrial matrix
Human-GEM MAR08684CC BY 4.0Reference data
L-cysteine+2-oxoglutarate(2-)2-oxo-3-sulfanylpropanoate+L-glutamate(1-)
Catalysed by GOT1 or CISD1
Reaction pageReversibleBalanced
Rhea RHEA:17441CC BY 4.0Reference data
2-oxo-3-sulfanylpropanoate+[thioredoxin]-dithiol[thioredoxin]-disulfide+hydrogen sulfide+pyruvate+hydron
Catalysed by MPST
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:21740CC BY 4.0Reference data
2-oxo-3-sulfanylpropanoate+L-cysteinyl-[protein]S-sulfanyl-L-cysteinyl-[protein]+pyruvate
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56296CC BY 4.0Reference data
L-cysteine+dioxygen+water2-oxo-3-sulfanylpropanoate+hydrogen peroxide+ammonium
Reaction pageDirection not assertedBalanced
Rhea RHEA:61256CC BY 4.0Reference data
2-oxobutanoate+L-cysteine2-oxo-3-sulfanylpropanoate+(2S)-2-aminobutanoate
Reaction pageDirection not assertedBalanced
Rhea RHEA:66108CC BY 4.0Reference data
2-oxo-3-sulfanylpropanoate+L-kynureninekynurenate+L-cysteine+water
Catalysed by AADAT
Reaction pageLeft to rightBalanced
Rhea RHEA:69104CC BY 4.0Reference data

Show the remaining 4