D-serine

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

505 compounds within 3 steps: 6 in 1, 95 in 2, 404 in 3

One step

pyruvateReach from here →
1. D-serine = pyruvate + NH4(+)
Catalysed by SRR
3-hydroxypyruvateReach from here →
1. D-serine + O2 + H2O = 3-hydroxypyruvate + H2O2 + NH4(+)
Catalysed by DAO
L-glutamineReach from here →
1. D-serine(in) + L-glutamine(out) + Na(+)(out) = D-serine(out) + L-glutamine(in) + Na(+)(in)
Catalysed by SLC1A5inner side of the membrane, outer side of the membraneOne of 4 routes
D-isoleucineReach from here →
1. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)
Catalysed by SLC7A10inner side of the membrane, outer side of the membrane
L-alanineReach from here →
1. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)
Catalysed by SLC7A10inner side of the membrane, outer side of the membraneOne of 6 routes
2-aminoprop-2-enoateReach from here →
1. D-serine = 2-aminoprop-2-enoate + H2O
Catalysed by SRR

Two steps

CHEBI:1146900Reach from here →
1. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)
2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)
Catalysed by SLC7A10inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes
2-hydroxybutyric acidReach from here →
1. D-serine = pyruvate + NH4(+)
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)
Catalysed by SRR, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

N(omega)-methyl-L-arginine

Reach from here →

Catalysed by SLC7A10, AGXT2inner side of the membrane, outer side of the membrane

acetoacetateReach from here →

Catalysed by SRRmitochondrial matrix, cytosolOne of 4 routes

2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →

Catalysed by SLC1A5, PFASinner side of the membrane, outer side of the membrane

acetylpyruvateReach from here →

Catalysed by SRR, FAHD1

all-trans-retinoic acidReach from here →

Catalysed by SRR, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

CHEBI:15570Reach from here →

Catalysed by SLC7A10inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

(S)-malateReach from here →

Catalysed by SRR, ME2One of 2 routes

L-leucineReach from here →

Catalysed by SLC7A10, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes

CHEBI:15699Reach from here →

Catalysed by SLC7A10, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 6 routes

alpha-D-glucosamine 6-phosphateReach from here →

Catalysed by SLC1A5, GFPT2, GFPT1inner side of the membrane, outer side of the membrane, cytosol

CHEBI:15971Reach from here →

Catalysed by SLC7A10, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

2-methyl-3-oxopropanoic acidReach from here →

Catalysed by SRR, AGXT2mitochondrial matrix

L-cystineReach from here →

Catalysed by SLC7A10, SLC7A9, SLC3A1inner side of the membrane, outer side of the membrane, extracellular space, cytosol

(R)-3-aminoisobutyric acidReach from here →

Catalysed by SLC7A10, AGXT2inner side of the membrane, outer side of the membrane, mitochondrial matrix

L-citrullineReach from here →

Catalysed by SLC7A10, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

L-valineReach from here →

Catalysed by SLC7A10, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 11 routes

oxaloacetateReach from here →

Catalysed by SRR, PCmitochondrial matrixOne of 3 routes

L-arginineReach from here →

Catalysed by SLC7A10, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes

CHEBI:16523Reach from here →

Catalysed by SLC1A5, SLC3A2, SLC7A10inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 2 routes

protein polypeptide chainReach from here →

Catalysed by SLC7A10inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

CHEBI:16633Reach from here →

Catalysed by SLC7A10, SCLYinner side of the membrane, outer side of the membrane, cytosol

(S)-lactateReach from here →

Catalysed by SRR, LDHA, LDHB, LDHC and 2 more

(R)-glycerateReach from here →

Catalysed by DAO, GRHPROne of 2 routes

2-oxobutanoateReach from here →

Catalysed by SRR, AGXT2

2-oxoglutaramateReach from here →

Catalysed by SRR, KYAT1cytosolOne of 5 routes

3-fumarylpyruvateReach from here →

Catalysed by SRR, FAHD1

CHEBI:16857Reach from here →

Catalysed by SLC7A10, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes

(R)-3-hydroxybutyric acidReach from here →

Catalysed by SRR, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosolOne of 2 routes

L-isoleucineReach from here →

Catalysed by SLC7A10, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 7 routes

CHEBI:17203Reach from here →

Catalysed by SLC7A10, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 7 routes

aceneuramateReach from here →

Catalysed by SRR, NPL

5'-deoxyadenosineReach from here →

Catalysed by SRR, TYW1B, TYW1

AH2Reach from here →

Catalysed by SLC7A10, MOCOSinner side of the membrane, outer side of the membrane

L-cysteineReach from here →

Catalysed by SLC7A10, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 15 routes

Ala-tRNA(Ala)Reach from here →

Catalysed by SLC7A10, AARS1inner side of the membrane, outer side of the membrane, cytosol

CHEBI:17895Reach from here →

Catalysed by SLC7A10, SLC7A5inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 8 routes

CHEBI:18019Reach from here →

Catalysed by SLC7A10, SLC7A6inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 4 routes

dTDPReach from here →

Catalysed by SRR, PKM, PKLRcytosol

CHEBI:18095Reach from here →

Catalysed by SLC7A10, SLC1A4inner side of the membrane, outer side of the membrane, extracellular space, cytosol

2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →

Catalysed by SLC1A5, PFASinner side of the membrane, outer side of the membrane, cytosol

2-aminoisobutanoateReach from here →

Catalysed by SLC7A10inner side of the membrane, outer side of the membraneOne of 2 routes

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by SRR, AGXT2