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Proteins/UNIPROT:Q9BY32
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions..
Function from UniProtKB (Q9BY32), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
31 statements
31 statements · 7 reference databases · Subject: ITPA · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
8 reactions
CHEBI:16497+waterdGMP+proton+diphosphate(3-)
Catalysed by ITPA
Reaction pageLeft to rightBalancedEC 3.6.1.9extracellular space
Human-GEM MAR02120CC BY 4.0Reference data
MAM01714c+waterdIMP+proton+diphosphate(3-)
Catalysed by ITPA
Reaction pageLeft to right
10 names
Resolves to: ITPA
Human-GEM MAR07879CC BY 4.0Reference data
water+CHEBI:10049proton+diphosphate(3-)+XMP
Catalysed by ITPA
Reaction pageLeft to rightBalancedEC 3.6.1.9cytosol
Human-GEM MAR08488CC BY 4.0Reference data
water+CHEBI:16039proton+CHEBI:17202+diphosphate(3-)
Catalysed by ITPA
Reaction pageLeft to rightBalancedEC 3.6.1.9cytosol
Human-GEM MAR08489CC BY 4.0Reference data
CHEBI:61382+waterdIMP+diphosphate(3-)+hydron
Catalysed by ITPA
Reaction pageLeft to rightBalanced
Rhea RHEA:28342CC BY 4.0Reference data
XTP+waterXMP+diphosphate(3-)+hydron
Catalysed by ITPA
Reaction pageLeft to rightBalanced
Rhea RHEA:28610CC BY 4.0Reference data
ITP+waterIMP+diphosphate(3-)+hydron
Catalysed by ITPA
Reaction pageLeft to rightBalanced
Rhea RHEA:29399CC BY 4.0Reference data
CHEBI:233529+waterCHEBI:233530+diphosphate(3-)+hydron
Catalysed by ITPA
Reaction pageLeft to rightBalanced
Rhea RHEA:83971CC BY 4.0Reference data