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Proteins/UNIPROT:P22079
Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism. Shows antibacterial properties against Pseudomonas aeruginosa. The lactoperoxidase-SCN(-)-H2O2 system shows antibacterial properties against Burkholderia cepacia and Haemophilus influenzae in vitro. Present in mammary and salivary gland secretions and may contribute to airway host defense against infection. May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity)..
Function from UniProtKB (P22079), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
43 statements
43 statements · 7 reference databases · Subject: LPO · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
26 reactions
2-hydroxyestrone+proton+hydrogen peroxideMAM01792c+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02061CC BY 4.0Reference data
3 names
Resolves to: LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02062CC BY 4.0Reference data
2-hydroxyestrone+proton+hydrogen peroxideMAM01792r+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2endoplasmic reticulum
Human-GEM MAR02063CC BY 4.0Reference data
MAM01000c+proton+hydrogen peroxideMAM01794c+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02076CC BY 4.0Reference data
MAM01000l+proton+hydrogen peroxideMAM01794l+2water
Catalysed by MPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02077CC BY 4.0Reference data
MAM01000r+proton+hydrogen peroxideMAM01794r+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2endoplasmic reticulum
Human-GEM MAR02078CC BY 4.0Reference data
MAM00413c+2water4-hydroxy-17beta-estradiol+hydrogen peroxide
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleBalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02088CC BY 4.0Reference data
MAM00413l+2water4-hydroxy-17beta-estradiol+hydrogen peroxide
Catalysed by MPO or PRDX6 or EPX or LPO
Reaction pageReversibleBalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02089CC BY 4.0Reference data
MAM00411c+2water2-hydroxy-17beta-estradiol+proton+hydrogen peroxide
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02099CC BY 4.0Reference data
MAM00411l+2water2-hydroxy-17beta-estradiol+proton+hydrogen peroxide
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02100CC BY 4.0Reference data
proton+hydrogen peroxide+thiocyanatewater+hypothiocyanous acid
Catalysed by LPO
Reaction pageReversibleBalancedEC 1.8.1.4extracellular space
Human-GEM MAR02529CC BY 4.0Reference data
3hydrogen peroxide+2MAM03330e6proton+2water+2sulfite+2MAM03525e
Catalysed by LPO
Reaction pageLeft to rightBalancedEC 1.11.1.7extracellular space
Human-GEM MAR02647CC BY 4.0Reference data