Compound
glutaryl-CoA
An acyl-CoA oxoanion that is the pentaanion of glutaryl-CoA arising from deprotonation of phosphate, diphosphate and carboxylic acid functions.
Definition from ChEBI (CHEBI:57378), read 2026-09-23. CC BY 4.0.
Structure
No three-dimensional record for this entry.
- Class
- Organic compound, anion
- Formula
- C26H37N7O19P3S
- Mass
- 876.601 g/mol
- Charge
- -5
- InChIKey
- SYKWLIJQEHRDNH-CKRMAKSASA-I
- SMILES
- CC(C)(COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-])[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCC(=O)[O-]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- KAT2AProteinUNIPROT:Q92830substrate ofInferred only114 paths90 endpoints
- GCDHProteinUNIPROT:Q92947substrate ofInferred only38 paths19 endpoints
- CPT1AProteinUNIPROT:P50416substrate ofInferred only28 paths28 endpoints
- ACOT8ProteinUNIPROT:O14734substrate ofInferred only16 paths16 endpoints
- ACOX1ProteinUNIPROT:Q15067substrate ofInferred only15 paths15 endpoints
- DBIProteinUNIPROT:P07108transported byInferred only9 paths9 endpoints
- ACOT4ProteinUNIPROT:Q8N9L9substrate ofInferred only9 paths9 endpoints
- CPT1BProteinUNIPROT:Q92523substrate ofInferred only8 paths8 endpoints
- CPT1CProteinUNIPROT:Q8TCG5substrate ofInferred only4 paths4 endpoints
What the reference databases state
Statements
23 statements
23 statements · 2 reference databases · Subject: glutaryl-CoA · Sources: Human-GEM, Rhea
- (2E)-butenoyl-CoA is converted to glutaryl-CoACompoundRhea RHEA:30847Inferred only
- glutaryl-CoA is converted to (2E)-butenoyl-CoACompoundRhea RHEA:30847Inferred only
- glutaryl-CoA is converted to (2E)-butenoyl-CoACompoundHuman-GEM MAR04243Inferred only
- glutaryl-CoA is converted to (2E)-glutaconyl-CoACompoundRhea RHEA:40315Inferred only
- 2-oxoadipate is converted to glutaryl-CoACompoundRhea RHEA:30795Inferred only
- glutaryl-CoA is converted to 2-oxoadipateCompoundRhea RHEA:30795Inferred only
- glutaryl-CoA is converted to glutarateCompoundRhea RHEA:40575Inferred only
- glutaryl-CoA is converted to glutarateCompoundRhea RHEA:14169Inferred only
- glutarate is converted to glutaryl-CoACompoundRhea RHEA:14169Inferred only
- glutaryl-CoA is a substrate of ACOT4ProteinRhea RHEA:40575Inferred only
- glutaryl-CoA is a substrate of ACOT8ProteinRhea RHEA:40575Inferred only
- glutaryl-CoA is a substrate of ACOX1ProteinRhea RHEA:40315Inferred only
Show the remaining 11
- glutaryl-CoA is a substrate of CPT1AProteinHuman-GEM MAR05991Inferred only
- glutaryl-CoA is a substrate of CPT1BProteinHuman-GEM MAR05991Inferred only
- glutaryl-CoA is a substrate of CPT1CProteinHuman-GEM MAR05991Inferred only
- glutaryl-CoA is a substrate of GCDHProteinHuman-GEM MAR04243Inferred only
- glutaryl-CoA is a substrate of GCDHProteinRhea RHEA:13389Inferred only
- glutaryl-CoA is a substrate of KAT2AProteinRhea RHEA:18009Inferred only
- glutaryl-CoA is a substrate of SUGCTProteinRhea RHEA:81711Inferred only
- glutaryl-CoA is a substrate of SUGCTProteinRhea RHEA:67900Inferred only
- glutaryl-CoA is a substrate of SUGCTProteinRhea RHEA:81723Inferred only
- glutaryl-CoA is a substrate of SUGCTProteinRhea RHEA:81715Inferred only
- glutaryl-CoA is transported by DBIProteinHuman-GEM MAR06485Inferred only
Reactions
21 reactions
FAD+glutaryl-CoA+protoncarbon dioxide+(2E)-butenoyl-CoA+FADH2
Catalysed by GCDH
Reaction pageLeft to rightBalancedEC 1.3.8.6mitochondrial matrix
Human-GEM MAR04243CC BY 4.0Reference data
glutaryl-CoA+proton+(S)-carnitineCHEBI:1146900+MAM03497c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR05991CC BY 4.0Reference data
CHEBI:1146900+MAM02899mMAM01701m+glutaryl-CoA
Catalysed by DLST
Reaction pageLeft to rightBalancedEC 2.3.1.61mitochondrial matrix
Human-GEM MAR06415CC BY 4.0Reference data
Transported by DBI
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR06485CC BY 4.0Reference data
FAD+glutaryl-CoAFADH2+MAM03964m
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR11513CC BY 4.0Reference data
FAD+glutaryl-CoAFADH2+MAM03613m
Reaction pageLeft to rightBalancedmitochondrial matrix
Human-GEM MAR11520CC BY 4.0Reference data
glutaryl-CoA+oxidized [electron-transfer flavoprotein]+2hydron(2E)-butenoyl-CoA+reduced [electron-transfer flavoprotein]+carbon dioxide
Catalysed by GCDH
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:13389CC BY 4.0Reference data
glutarate+ATP(4-)+coenzyme A(4-)glutaryl-CoA+ADP(3-)+hydrogenphosphate
Reaction pageDirection not assertedBalanced
Rhea RHEA:14169CC BY 4.0Reference data
glutaryl-CoA+L-lysyl-[protein]N(6)-glutaryl-L-lysyl-[protein]+coenzyme A(4-)+hydron
Catalysed by KAT2A
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18009CC BY 4.0Reference data
glutaryl-CoA+oxidized [electron-transfer flavoprotein]+hydron(2E)-glutaconyl-CoA+reduced [electron-transfer flavoprotein]
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:20589CC BY 4.0Reference data
2-oxoadipate+NAD(1-)+coenzyme A(4-)glutaryl-CoA+carbon dioxide+NADH(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:30795CC BY 4.0Reference data
glutaryl-CoA+FAD(3-)+2hydron(2E)-butenoyl-CoA+FADH2(2-)+carbon dioxide
Reaction pageDirection not assertedBalanced
Rhea RHEA:30847CC BY 4.0Reference data
Other names
6 names
Resolves to: glutaryl-CoA
- Also called
- 4-carboxylatobutanoyl-CoA(5-)4-carboxylatobutanoyl-CoA(5−)glutaryl-CoA pentaanionglutaryl-coenzyme A(5-)glutaryl-coenzyme A(5−)
- Systematic name
- 3'-phosphonatoadenosine 5'-{3-[(3R)-4-{[3-({2-[(4-carboxylatobutanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] diphosphate}