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Proteins/UNIPROT:P19367
Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine. Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome..
Function from UniProtKB (P19367), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
5 rows
431 statements
431 statements · 8 reference databases · Subject: HK1 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
17 reactions
ATP+beta-D-fructoseADP+keto-D-fructose 6-phosphate+proton
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04319CC BY 4.0Reference data
4 names
Resolves to: HK1
Reaction pageLeft to rightBalancedEC 2.7.1.1, 2.7.1.2, 2.7.1.147cytosol
Human-GEM MAR04394CC BY 4.0Reference data
D-glucose+CHEBI:16039D-glucopyranose 6-phosphate+proton+CHEBI:17808
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04486CC BY 4.0Reference data
CHEBI:16284+D-glucoseCHEBI:16174+D-glucopyranose 6-phosphate+proton
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04487CC BY 4.0Reference data
beta-D-fructose+CHEBI:16039keto-D-fructose 6-phosphate+proton+CHEBI:17808
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04488CC BY 4.0Reference data
CHEBI:16284+beta-D-fructoseCHEBI:16174+keto-D-fructose 6-phosphate+proton
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04489CC BY 4.0Reference data
ATP+D-mannoseADP+proton+MAM02455c
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04490CC BY 4.0Reference data
CHEBI:16039+D-mannoseproton+CHEBI:17808+MAM02455c
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04492CC BY 4.0Reference data
CHEBI:16284+D-mannoseCHEBI:16174+proton+MAM02455c
Catalysed by HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04493CC BY 4.0Reference data
ATP+glucosamineADP+alpha-D-glucosamine 6-phosphate+proton
Catalysed by GCK or HKDC1 or HK1 or HK2 or HK3
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04494CC BY 4.0Reference data
glucosamine+CHEBI:16039alpha-D-glucosamine 6-phosphate+proton+CHEBI:17808
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04495CC BY 4.0Reference data
CHEBI:16284+glucosamineCHEBI:16174+alpha-D-glucosamine 6-phosphate+proton
Catalysed by HKDC1 or HK1 or HK2
Reaction pageLeft to rightBalancedEC 2.7.1.1cytosol
Human-GEM MAR04496CC BY 4.0Reference data