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Proteins/UNIPROT:Q9NR45
Catalyzes the condensation of phosphoenolpyruvate (PEP) and N-acetylmannosamine 6-phosphate (ManNAc-6-P) to synthesize N-acetylneuraminate-9-phosphate (Neu5Ac-9-P). Also catalyzes the condensation of PEP and D-mannose 6-phosphate (Man-6-P) to produce 3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate (KDN-9-P). Neu5Ac-9-P and KDN-9-P are the phosphorylated forms of sialic acids N-acetylneuraminic acid (Neu5Ac) and deaminoneuraminic acid (KDN), respectively. Required for brain and skeletal development..
Function from UniProtKB (Q9NR45), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
46 statements
46 statements · 5 reference databases · Subject: NANS · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea
4 reactions
water+aldehydo-N-acetyl-D-mannosamine 6-phosphate+phosphoenolpyruvic acidN-acetylneuraminate 9-phosphate+phosphate(3-)
Catalysed by NANS
Reaction pageLeft to rightBalancedEC 2.5.1.56, 2.5.1.57cytosol
Human-GEM MAR04529CC BY 4.0Reference data
water+MAM02455c+phosphoenolpyruvic acidMAM00772c+phosphate(3-)
Catalysed by NANS
5 names
Resolves to: NANS
Human-GEM MAR08371CC BY 4.0Reference data
aldehydo-D-mannose 6-phosphate+phosphoenolpyruvate+water3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphate+hydrogenphosphate
Catalysed by NANS
Reaction pageLeft to rightBalanced
Rhea RHEA:49200CC BY 4.0Reference data
aldehydo-N-acetyl-D-mannosamine 6-phosphate+phosphoenolpyruvate+waterN-acetylneuraminate 9-phosphate+hydrogenphosphate
Catalysed by NANS
Reaction pageLeft to rightBalanced
Rhea RHEA:80835CC BY 4.0Reference data