Compound
3-hydroxypyruvic acid
A 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is substituted by a hydroxy group. It is an intermediate involved in the glycine and serine metabolism.
Definition from ChEBI (CHEBI:30841), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- LDHAProteinUNIPROT:P00338substrate ofInferred only50 paths50 endpoints
- LDHBProteinUNIPROT:P07195substrate ofInferred only23 paths23 endpoints
- GRHPRProteinUNIPROT:Q9UBQ7substrate ofInferred only14 paths7 endpoints
- LDHCProteinUNIPROT:P07864substrate ofInferred only9 paths9 endpoints
- LDHDProteinUNIPROT:Q86WU2substrate ofInferred only5 paths5 endpoints
- LDHAL6BProteinUNIPROT:Q9BYZ2substrate ofInferred only5 paths5 endpoints
- LDHAL6AProteinUNIPROT:Q6ZMR3substrate ofInferred only3 paths3 endpoints
What the reference databases state
Statements
14 statements
14 statements · 1 reference database · Subject: 3-hydroxypyruvic acid · Sources: Human-GEM
- 3-hydroxypyruvic acid is converted to (R)-glycerateCompoundHuman-GEM MAR04465Inferred only
- 3-hydroxypyruvic acid is converted to (R)-glycerateCompoundHuman-GEM MAR08782Inferred only
- 3-hydroxypyruvic acid is converted to 2-hydroxy-3-oxopropanoateCompoundHuman-GEM MAR04466Inferred only
- 3-hydroxypyruvic acid is converted to glycolaldehydeCompoundHuman-GEM MAR08774Inferred only
- 3-hydroxypyruvic acid is converted to glycolaldehydeCompoundHuman-GEM MAR08777Inferred only
- 3-hydroxypyruvic acid is a substrate of GRHPRProteinHuman-GEM MAR08782Inferred only
- 3-hydroxypyruvic acid is a substrate of GRHPRProteinHuman-GEM MAR04465Inferred only
- 3-hydroxypyruvic acid is a substrate of HYIProteinHuman-GEM MAR04466Inferred only
- 3-hydroxypyruvic acid is a substrate of LDHAProteinHuman-GEM MAR01453Inferred only
- 3-hydroxypyruvic acid is a substrate of LDHAL6AProteinHuman-GEM MAR01453Inferred only
- 3-hydroxypyruvic acid is a substrate of LDHAL6BProteinHuman-GEM MAR01453Inferred only
- 3-hydroxypyruvic acid is a substrate of LDHBProteinHuman-GEM MAR01453Inferred only
Show the remaining 2
- 3-hydroxypyruvic acid is a substrate of LDHCProteinHuman-GEM MAR01453Inferred only
- 3-hydroxypyruvic acid is a substrate of LDHDProteinHuman-GEM MAR01453Inferred only
Reactions
10 reactions
3proton+23-hydroxypyruvic acid+NADH(2-)NAD(+)+2MAM03620c
Catalysed by LDHB or LDHA or LDHC or LDHAL6A or LDHD or LDHAL6B
Reaction pageLeft to rightUnbalancedEC 1.1.1.27GO:0005829
Human-GEM MAR01453CC BY 4.0Reference data
pyruvate+L-seryl residueL-alanine+3-hydroxypyruvic acid
Catalysed by AGXT
Reaction pageLeft to rightBalancedEC 2.6.1.51GO:0005829
Human-GEM MAR04198CC BY 4.0Reference data
proton+3-hydroxypyruvic acid+NADPH(4-)(R)-glycerate+NADP(3-)
Catalysed by GRHPR
Reaction pageLeft to rightBalancedEC 1.1.1.79, 1.1.1.81GO:0005829
Human-GEM MAR04465CC BY 4.0Reference data
3-hydroxypyruvic acid2-hydroxy-3-oxopropanoate
Catalysed by HYI
Reaction pageLeft to rightBalancedEC 5.3.1.22GO:0005829
Human-GEM MAR04466CC BY 4.0Reference data
pyruvate+L-seryl residueL-alanine+3-hydroxypyruvic acid
Catalysed by AGXT
Reaction pageLeft to rightBalancedEC 2.6.1.51GO:0005777
Human-GEM MAR04467CC BY 4.0Reference data
3-hydroxypyruvic acid3-hydroxypyruvic acid
Reaction pageReversibleBalancedGO:0005829, GO:0005777
Human-GEM MAR04469CC BY 4.0Reference data
proton+3-hydroxypyruvic acidcarbon dioxide+glycolaldehyde
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR08774CC BY 4.0Reference data
3-hydroxypyruvic acid3-hydroxypyruvic acid
Reaction pageReversibleBalancedGO:0005829, GO:0005759
Human-GEM MAR08776CC BY 4.0Reference data
proton+3-hydroxypyruvic acidcarbon dioxide+glycolaldehyde
Reaction pageLeft to rightBalancedGO:0005759
Human-GEM MAR08777CC BY 4.0Reference data
proton+3-hydroxypyruvic acid+NADH(2-)(R)-glycerate+NAD(+)
Catalysed by GRHPR
Reaction pageLeft to rightBalancedEC 1.1.1.79, 1.1.1.81GO:0005829
Human-GEM MAR08782CC BY 4.0Reference data
Other names
2 names
Resolves to: 3-hydroxypyruvic acid
- Also called
- Hydroxypyruvic acid
- Systematic name
- 3-hydroxy-2-oxopropanoic acid